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- Q4320074 subject Q7428637.
- Q4320074 subject Q8645495.
- Q4320074 subject Q8729038.
- Q4320074 subject Q8965786.
- Q4320074 subject Q9056368.
- Q4320074 abstract "Nicocodeine (Lyopect, Tusscodin) is an opioid analgesic and cough suppressant, an ester of codeine closely related to dihydrocodeine and the codeine analogue of nicomorphine. It is not commonly used in most countries, but has activity similar to other opiates. Nicocodeine and nicomorphine were introduced in 1957 by Lannacher Heilmittel of Austria. Nicocodeine is metabolised in the liver by demethylation to produce nicomorphine, also known as 6-nicotinoylmorphine, and subsequently further metabolised to morphine. Side effects are similar to those of other opiates and include itching, nausea and respiratory depression. The drug was first synthesised in the first years of the 20th Century in what was then the Austro-Hungarian Empire, as were nicomorphine and nicodicodeine.Nicocodeine is almost always used as the hydrochloride salt, which has a free base conversion ratio of .917. In the past, the tartrate, bitartrate, phosphate, hydrobromide, methiodide, hydroiodide, and sulphate were used in research or as pharmaceuticals.Nicocodeine is regulated in most cases as is codeine and similar weak opiate drugs like ethylmorphine, benzylmorphine, dihydrocodeine and its other close derivatives like acetyldihydrocodeine (although not the stronger hydrocodone or oxycodone, which are regulated like morphine) and others of this class in the laws of countries and the Single Convention On Narcotic Drugs. One notable example is the fact that nicocodeine is a Schedule I/Narcotic controlled substance in the United States along with heroin as nicocodeine was never introduced for medical use in the United States.Nicodicodeine is a similar drug which is to nicocodeine as codeine is to dihydrocodeine. The metabolites of nicodicodeine include dihydromorphine where nicocodeine is turned into morphine as noted above.Nicocodeine cough medicines are available as syrups, extended-release syrups, and sublingual drops. Analgesic preparations are also in the form of sublingial drops and tablets for oral administration. Nicocodeine is approximately the same strength as hydrocodone; it has a faster onset of action.The 2013 DEA annual production quota for nicocodeine and its two related drugs are zero. Nicocodeine's ACSCN is 9309. Nicodicodeine is not assigned an ACSCN and is presumably controlled as either an ester of dihydromorphine or derivative of nicomorphine.".
- Q4320074 atcPrefix "none".
- Q4320074 casNumber "3688-66-2".
- Q4320074 casSupplemental "(HCl)".
- Q4320074 fdaUniiCode "DYX391P13E".
- Q4320074 iupacName "(5α,6α)-3-methoxy-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6-yl nicotinate".
- Q4320074 pubchem "5463872".
- Q4320074 thumbnail Nicocodeine.svg?width=300.
- Q4320074 wikiPageWikiLink Q101487.
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- Q4320074 wikiPageWikiLink Q377270.
- Q4320074 wikiPageWikiLink Q407535.
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- Q4320074 wikiPageWikiLink Q411441.
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- Q4320074 wikiPageWikiLink Q427523.
- Q4320074 wikiPageWikiLink Q4673302.
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- Q4320074 wikiPageWikiLink Q7028925.
- Q4320074 wikiPageWikiLink Q7030497.
- Q4320074 wikiPageWikiLink Q7428637.
- Q4320074 wikiPageWikiLink Q81225.
- Q4320074 wikiPageWikiLink Q8645495.
- Q4320074 wikiPageWikiLink Q8729038.
- Q4320074 wikiPageWikiLink Q8965786.
- Q4320074 wikiPageWikiLink Q9056368.
- Q4320074 atcPrefix "none".
- Q4320074 casNumber "3688".
- Q4320074 iupacName "-3".
- Q4320074 pubchem "5463872".
- Q4320074 unii "DYX391P13E".
- Q4320074 type ChemicalSubstance.
- Q4320074 type Drug.
- Q4320074 type ChemicalObject.
- Q4320074 type Thing.
- Q4320074 type Q8386.
- Q4320074 comment "Nicocodeine (Lyopect, Tusscodin) is an opioid analgesic and cough suppressant, an ester of codeine closely related to dihydrocodeine and the codeine analogue of nicomorphine. It is not commonly used in most countries, but has activity similar to other opiates. Nicocodeine and nicomorphine were introduced in 1957 by Lannacher Heilmittel of Austria.".
- Q4320074 label "Nicocodeine".
- Q4320074 depiction Nicocodeine.svg.