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- Q4316436 abstract "Neurogranin is a calmodulin-binding protein expressed exclusively in the brain, particularly in dendritic spines, and participating in the protein kinase C signaling pathway. Neurogranin is the main postsynaptic protein regulating the availability of calmodulin, binding to it in the absence of calcium. Phosphorylation by protein kinase C lowers its binding ability. NRGN gene expression is controlled by thyroid hormones. Human neurogranin consists of 78 amino acids.One study tells of potential link of neurogranin gene to the heightened risk of schizophrenia in males, another study gives evidence of lowered neurogranin immunoreactivity in the brains of people suffering from schizophrenia.Prior to its identification in the bovine and rat brain in 1991, neurogranin was known as a putative protein kinase C-phosphorylated protein named p17. Human neurogranin was cloned in 1997 and turned out to be 96% identical to the rat protein.".
- Q4316436 arm "q".
- Q4316436 band "24".
- Q4316436 chromosome "11".
- Q4316436 entrezgene "4900".
- Q4316436 hgncid "8000".
- Q4316436 omim "602350".
- Q4316436 refseq "NM_006176".
- Q4316436 symbol "NRGN".
- Q4316436 uniprot "Q92686".
- Q4316436 wikiPageWikiLink Q16399.
- Q4316436 wikiPageWikiLink Q242736.
- Q4316436 wikiPageWikiLink Q36396.
- Q4316436 wikiPageWikiLink Q41112.
- Q4316436 wikiPageWikiLink Q420877.
- Q4316436 wikiPageWikiLink Q5023049.
- Q4316436 wikiPageWikiLink Q706.
- Q4316436 wikiPageWikiLink Q759183.
- Q4316436 wikiPageWikiLink Q8066.
- Q4316436 wikiPageWikiLink Q902079.
- Q4316436 arm "q".
- Q4316436 band "24".
- Q4316436 chromosome "11".
- Q4316436 entrezgene "4900".
- Q4316436 hgncid "8000".
- Q4316436 name "neurogranin".
- Q4316436 omim "602350".
- Q4316436 refseq "NM_006176".
- Q4316436 symbol "NRGN".
- Q4316436 uniprot "Q92686".
- Q4316436 type Biomolecule.
- Q4316436 type Protein.
- Q4316436 type Thing.
- Q4316436 type Q206229.
- Q4316436 type Q8054.
- Q4316436 comment "Neurogranin is a calmodulin-binding protein expressed exclusively in the brain, particularly in dendritic spines, and participating in the protein kinase C signaling pathway. Neurogranin is the main postsynaptic protein regulating the availability of calmodulin, binding to it in the absence of calcium. Phosphorylation by protein kinase C lowers its binding ability. NRGN gene expression is controlled by thyroid hormones.".
- Q4316436 label "Neurogranin".
- Q4316436 name "neurogranin (protein kinase C substrate, RC3)".