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- Q429449 subject Q7139608.
- Q429449 subject Q8645495.
- Q429449 subject Q8729038.
- Q429449 subject Q9056368.
- Q429449 abstract "6-Methylenedihydrodesoxymorphine (6-MDDM) is an opiate analogue structurally related to desomorphine that is a derivative of hydromorphone, where the 6-ketone group has been replaced by a methylene group. It has sedative and analgesic effects.6-Methylenedihydrodesoxymorphine is a potent μ-opioid agonist, 80x stronger than morphine. Compared to morphine it has a faster onset of action and similar duration of effects. It produces around the same degree of respiratory depression as morphine, but less inhibition of gastrointestinal motility. Animal studies show it to be a potent analgesic which produces significant analgesic effects even at low doses while inducing comparatively few side effects, however it has never been developed for medical use in humans.6-Methylenedihydrodesoxymorphine is synthesised in two steps; first a Wittig reaction is used, reacting hydrocodone with methylenetriphenylphosphorane and an alkyl lithium reagent in diethyl ether to form 6-Methylenedihydrodesoxycodeine. The 3-methoxy group is then cleaved to hydroxy, by reaction with pyridine. The second step tends to be incomplete and often gives fairly low yields, but these can be improved by changing the reaction conditions.".
- Q429449 casNumber "3414-84-4".
- Q429449 iupacName "4,5-α-Epoxy-17-methyl-6-methylenemorphinan-3-ol".
- Q429449 pubchem "5492874".
- Q429449 thumbnail 6-Methylenedihydrodesoxymorphine.svg?width=300.
- Q429449 wikiPageWikiLink Q104116.
- Q429449 wikiPageWikiLink Q14911924.
- Q429449 wikiPageWikiLink Q1641494.
- Q429449 wikiPageWikiLink Q170744.
- Q429449 wikiPageWikiLink Q173235.
- Q429449 wikiPageWikiLink Q178436.
- Q429449 wikiPageWikiLink Q202218.
- Q429449 wikiPageWikiLink Q2026938.
- Q429449 wikiPageWikiLink Q210385.
- Q429449 wikiPageWikiLink Q303646.
- Q429449 wikiPageWikiLink Q389934.
- Q429449 wikiPageWikiLink Q411441.
- Q429449 wikiPageWikiLink Q422163.
- Q429449 wikiPageWikiLink Q4353252.
- Q429449 wikiPageWikiLink Q6823966.
- Q429449 wikiPageWikiLink Q7139608.
- Q429449 wikiPageWikiLink Q7485453.
- Q429449 wikiPageWikiLink Q8044946.
- Q429449 wikiPageWikiLink Q81225.
- Q429449 wikiPageWikiLink Q847705.
- Q429449 wikiPageWikiLink Q8645495.
- Q429449 wikiPageWikiLink Q8729038.
- Q429449 wikiPageWikiLink Q899597.
- Q429449 wikiPageWikiLink Q9056368.
- Q429449 wikiPageWikiLink Q909735.
- Q429449 casNumber "3414".
- Q429449 iupacName "45".
- Q429449 pubchem "5492874".
- Q429449 type ChemicalSubstance.
- Q429449 type Drug.
- Q429449 type ChemicalObject.
- Q429449 type Thing.
- Q429449 type Q8386.
- Q429449 comment "6-Methylenedihydrodesoxymorphine (6-MDDM) is an opiate analogue structurally related to desomorphine that is a derivative of hydromorphone, where the 6-ketone group has been replaced by a methylene group. It has sedative and analgesic effects.6-Methylenedihydrodesoxymorphine is a potent μ-opioid agonist, 80x stronger than morphine. Compared to morphine it has a faster onset of action and similar duration of effects.".
- Q429449 label "6-Methylenedihydrodesoxymorphine".
- Q429449 depiction 6-Methylenedihydrodesoxymorphine.svg.