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- Q425517 subject Q6431098.
- Q425517 subject Q7215865.
- Q425517 subject Q8257162.
- Q425517 subject Q9094579.
- Q425517 abstract "Retinoic acid is a metabolite of vitamin A (retinol) that mediates the functions of vitamin A required for growth and development. Retinoic acid is required in chordate animals, which includes all higher animals from fish to humans. During early embryonic development, retinoic acid generated in a specific region of the embryo helps determine position along the embryonic anterior/posterior axis by serving as an intercellular signaling molecule that guides development of the posterior portion of the embryo. It acts through Hox genes, which ultimately control anterior/posterior patterning in early developmental stages.The key role of retinoic acid in embryonic development mediates the high teratogenicity of retinoid pharmaceuticals, such as isotretinoin used for treatment of cancer and acne. Oral megadoses of pre-formed vitamin A (retinyl palmitate), and retinoic acid itself, also have teratogenic potential by this same mechanism.".
- Q425517 iupacName "(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid".
- Q425517 thumbnail All-trans-Retinsäure.svg?width=300.
- Q425517 wikiPageExternalLink ?ligand=REA.
- Q425517 wikiPageWikiLink Q1054713.
- Q425517 wikiPageWikiLink Q10915.
- Q425517 wikiPageWikiLink Q179399.
- Q425517 wikiPageWikiLink Q18225.
- Q425517 wikiPageWikiLink Q253149.
- Q425517 wikiPageWikiLink Q2838685.
- Q425517 wikiPageWikiLink Q287029.
- Q425517 wikiPageWikiLink Q29417.
- Q425517 wikiPageWikiLink Q306135.
- Q425517 wikiPageWikiLink Q3454518.
- Q425517 wikiPageWikiLink Q36961.
- Q425517 wikiPageWikiLink Q407693.
- Q425517 wikiPageWikiLink Q410754.
- Q425517 wikiPageWikiLink Q422001.
- Q425517 wikiPageWikiLink Q424976.
- Q425517 wikiPageWikiLink Q631521.
- Q425517 wikiPageWikiLink Q6431098.
- Q425517 wikiPageWikiLink Q7215865.
- Q425517 wikiPageWikiLink Q766195.
- Q425517 wikiPageWikiLink Q79928.
- Q425517 wikiPageWikiLink Q8257162.
- Q425517 wikiPageWikiLink Q9094579.
- Q425517 wikiPageWikiLink Q938107.
- Q425517 iupacname "-37".
- Q425517 name "All-trans-retinoic acid".
- Q425517 type ChemicalCompound.
- Q425517 type ChemicalSubstance.
- Q425517 type ChemicalObject.
- Q425517 type Thing.
- Q425517 type Q11173.
- Q425517 comment "Retinoic acid is a metabolite of vitamin A (retinol) that mediates the functions of vitamin A required for growth and development. Retinoic acid is required in chordate animals, which includes all higher animals from fish to humans.".
- Q425517 label "Retinoic acid".
- Q425517 depiction All-trans-Retinsäure.svg.
- Q425517 name "All-trans-retinoic acid".