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- Q422868 subject Q8501360.
- Q422868 subject Q9089708.
- Q422868 abstract "Platelet-derived growth factor (PDGF) is one of the numerous growth factors, or proteins that regulate cell growth and division. In particular, it plays a significant role in blood vessel formation (angiogenesis), the growth of blood vessels from already-existing blood vessel tissue. Uncontrolled angiogenesis is a characteristic of cancer. In chemical terms, platelet-derived growth factor is a dimeric glycoprotein composed of two A (-AA) or two B (-BB) chains or a combination of the two (-AB).PDGF is a potent mitogen for cells of mesenchymal origin, including fibroblasts, smooth muscle cells and glial cells. In both mouse and human, the PDGF signalling network consists of four ligands, PDGFA-D, and two receptors, PDGFRalpha and PDGFRbeta. All PDGFs function as secreted, disulphide-linked homodimers, but only PDGFA and B can form functional heterodimers.Though PDGF is synthesized, stored (in the alpha granules of platelets), and released by platelets upon activation, it is also produced by a plethora of cells including smooth muscle cells, activated macrophages, and endothelial cellsRecombinant PDGF is used in medicine to help heal chronic ulcers and in orthopedic surgery and periodontistry to treat bone loss.".
- Q422868 symbol "PDGF".
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- Q422868 wikiPageWikiLink Q8501360.
- Q422868 wikiPageWikiLink Q9089708.
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- Q422868 symbol "PDGF".
- Q422868 type Biomolecule.
- Q422868 type Protein.
- Q422868 type Thing.
- Q422868 type Q206229.
- Q422868 type Q8054.
- Q422868 comment "Platelet-derived growth factor (PDGF) is one of the numerous growth factors, or proteins that regulate cell growth and division. In particular, it plays a significant role in blood vessel formation (angiogenesis), the growth of blood vessels from already-existing blood vessel tissue. Uncontrolled angiogenesis is a characteristic of cancer.".
- Q422868 label "Platelet-derived growth factor".