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Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q421237> ?p ?o }

• Q421237 subject Q8479306.
• Q421237 abstract "Cannabinoid receptors, located in the brain, are part of the Endocannabinoid system which is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory.Cannabinoid receptors are of a class of cell membrane receptors under the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, produced by the mammillary body; plant cannabinoids (such as Cannabidiol, produced by the cannabis plant); and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and plant cannabinoids are lipophilic, such as fat soluble compounds.There are currently two known subtypes of cannabinoid receptors, termed CB1 and CB2. The CB1 receptor is expressed mainly in the brain (central nervous system or "CNS"), but also in the lungs, liver and kidneys. The CB2 receptor is expressed mainly in the immune system and in hematopoietic cells. Mounting evidence suggests that there are novel cannabinoid receptors that is, non-CB1 and non-CB2, which are expressed in endothelial cells and in the CNS. In 2007, the binding of several cannabinoids to the G protein-coupled receptor GPR55 in the brain was described.The protein sequences of CB1 and CB2 receptors are about 44% similar. When only the transmembrane regions of the receptors are considered, amino acid similarity between the two receptor subtypes is approximately 68%. In addition, minor variations in each receptor have been identified. Cannabinoids bind reversibly and stereo-selectively to the cannabinoid receptors. Subtype selective cannabinoids have been developed which theoretically may have advantages for treatment of certain diseases such as obesity.".
• Q421237 arm "p".
• Q421237 arm "q".
• Q421237 band "14".
• Q421237 chromosome "1".
• Q421237 chromosome "6".
• Q421237 entrezgene "1268".
• Q421237 entrezgene "1269".
• Q421237 hgncid "2159".
• Q421237 hgncid "2160".
• Q421237 locusSupplementaryData "-q15".
• Q421237 omim "114610".
• Q421237 omim "605051".
• Q421237 refseq "NM_001841".
• Q421237 refseq "NM_033181".
• Q421237 symbol "CNR".
• Q421237 symbol "CNR1".
• Q421237 symbol "CNR2".
• Q421237 thumbnail Cb1_cb2_structure.png?width=300.
• Q421237 uniprot "P21554".
• Q421237 uniprot "P34972".
• Q421237 wikiPageExternalLink ChapterMenuForward?chapterID=1279.
• Q421237 wikiPageExternalLink www.endocannabinoid.net.
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