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- Q419383 subject Q18924462.
- Q419383 subject Q20870732.
- Q419383 subject Q6442932.
- Q419383 subject Q7145146.
- Q419383 subject Q8679151.
- Q419383 subject Q9052323.
- Q419383 abstract "Desflurane (1,2,2,2-tetrafluoroethyl difluoromethyl ether) is a highly fluorinated methyl ethyl ether used for maintenance of general anesthesia. Like halothane, enflurane, and isoflurane, it is a racemic mixture of (R) and (S) optical isomers (enantiomers). Together with sevoflurane, it is gradually replacing isoflurane for human use, except in economically undeveloped areas, where its high cost precludes its use. It has the most rapid onset and offset of the volatile anesthetic drugs used for general anesthesia due to its low solubility in blood.Some drawbacks of desflurane are its low potency, its pungency and its high cost. It may cause tachycardia and airway irritability when administered at concentrations greater than 10 vol%. Due to this airway irritability, desflurane is infrequently used to induce anesthesia via inhalation techniques.Though it vaporises very readily, it is a liquid at room temperature. Anaesthetic machines are fitted with a specialized anaesthetic vaporiser unit that heats liquid desflurane to a constant temperature. This enables the agent to be available at a constant vapor pressure, negating the effects fluctuating ambient temperatures would otherwise have on its concentration imparted into the fresh gas flow of the anesthesia machine.Desflurane, along with enflurane and to a lesser extent isoflurane, has been shown to react with the carbon dioxide absorbent in anesthesia circuits to produce detectable levels of carbon monoxide through degradation of the anesthetic agent. The CO2 absorbent Baralyme, when dried, is most culpable for the production of carbon monoxide from desflurane degradation, although it is also seen with soda lime absorbent as well. Dry conditions in the carbon dioxide absorbent are conducive to this phenomenon, such as those resulting from high fresh gas flows.".
- Q419383 atcPrefix "N01".
- Q419383 atcSuffix "AB07".
- Q419383 casNumber "57041-67-5".
- Q419383 chEBI "4445".
- Q419383 drugbank "DB01189".
- Q419383 fdaUniiCode "CRS35BZ94Q".
- Q419383 iupacName "2-(difluoromethoxy)-1,1,1,2-tetrafluoro-ethane".
- Q419383 pubchem "42113".
- Q419383 thumbnail Desflurane2.svg?width=300.
- Q419383 wikiPageExternalLink dokserv?idn=977851818&dok_var=d1&dok_ext=pdf&filename=977851818.pdf.
- Q419383 wikiPageExternalLink diss.pdf.
- Q419383 wikiPageWikiLink Q1003183.
- Q419383 wikiPageWikiLink Q1316377.
- Q419383 wikiPageWikiLink Q166543.
- Q419383 wikiPageWikiLink Q167336.
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- Q419383 wikiPageWikiLink Q177974.
- Q419383 wikiPageWikiLink Q182854.
- Q419383 wikiPageWikiLink Q18924462.
- Q419383 wikiPageWikiLink Q1936963.
- Q419383 wikiPageWikiLink Q1997.
- Q419383 wikiPageWikiLink Q2025.
- Q419383 wikiPageWikiLink Q20870732.
- Q419383 wikiPageWikiLink Q209583.
- Q419383 wikiPageWikiLink Q2649417.
- Q419383 wikiPageWikiLink Q2661322.
- Q419383 wikiPageWikiLink Q29539.
- Q419383 wikiPageWikiLink Q32921.
- Q419383 wikiPageWikiLink Q412256.
- Q419383 wikiPageWikiLink Q413918.
- Q419383 wikiPageWikiLink Q416740.
- Q419383 wikiPageWikiLink Q418536.
- Q419383 wikiPageWikiLink Q419394.
- Q419383 wikiPageWikiLink Q426887.
- Q419383 wikiPageWikiLink Q4750815.
- Q419383 wikiPageWikiLink Q4918396.
- Q419383 wikiPageWikiLink Q4927528.
- Q419383 wikiPageWikiLink Q60147.
- Q419383 wikiPageWikiLink Q6442932.
- Q419383 wikiPageWikiLink Q7145146.
- Q419383 wikiPageWikiLink Q754282.
- Q419383 wikiPageWikiLink Q7942.
- Q419383 wikiPageWikiLink Q8679151.
- Q419383 wikiPageWikiLink Q901028.
- Q419383 wikiPageWikiLink Q903628.
- Q419383 wikiPageWikiLink Q9052323.
- Q419383 wikiPageWikiLink Q909194.
- Q419383 atcPrefix "N01".
- Q419383 atcSuffix "AB07".
- Q419383 casNumber "57041".
- Q419383 chebi "4445".
- Q419383 drugbank "DB01189".
- Q419383 iupacName "2".
- Q419383 pubchem "42113".
- Q419383 unii "CRS35BZ94Q".
- Q419383 type ChemicalSubstance.
- Q419383 type Drug.
- Q419383 type ChemicalObject.
- Q419383 type Thing.
- Q419383 type Q8386.
- Q419383 comment "Desflurane (1,2,2,2-tetrafluoroethyl difluoromethyl ether) is a highly fluorinated methyl ethyl ether used for maintenance of general anesthesia. Like halothane, enflurane, and isoflurane, it is a racemic mixture of (R) and (S) optical isomers (enantiomers). Together with sevoflurane, it is gradually replacing isoflurane for human use, except in economically undeveloped areas, where its high cost precludes its use.".
- Q419383 label "Desflurane".
- Q419383 depiction Desflurane2.svg.