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- Q417465 subject Q7297892.
- Q417465 subject Q8805811.
- Q417465 subject Q9052781.
- Q417465 subject Q9458667.
- Q417465 abstract "Mitotane, also known as o,p'-DDD (Lysodren), is an antineoplastic medication used in the treatment of adrenocortical carcinoma. It is an isomer of DDD and is a derivative of DDT. Its main use is in those patients who have persistent disease despite surgical resection, those who are not surgical candidates, or those who have metastatic disease. It has been produced by Bristol Myers Squibb SpA but it is marketed as an orphan drug due to the small number of patients in need of it. A 2007 study of 177 patients shows a significant increase in the recurrence-free interval after radical surgery followed by mitotane when compared to surgery alone.Mitotane alters steroid peripheral metabolism, directly suppresses the adrenal cortex and alters cortisone metabolism leading to hypocortisolism. Side effects as reported by Schteinberg et al. include anorexia and nausea (88%), diarrhea (38%), vomiting (23%), decreased memory and ability to concentrate (50%), rash (23%), gynecomastia (50%), arthralgia (19%), and leukopenia (7%).Its trade name is Lysodren.".
- Q417465 atcPrefix "L01".
- Q417465 atcSuffix "XX23".
- Q417465 bioavailability "40.0".
- Q417465 casNumber "53-19-0".
- Q417465 drugbank "DB00648".
- Q417465 fdaUniiCode "78E4J5IB5J".
- Q417465 iupacName "(RS)-1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)-ethyl]-benzene".
- Q417465 pubchem "4211".
- Q417465 thumbnail Mitotane.svg?width=300.
- Q417465 wikiPageExternalLink 53-19-0-eng.php.
- Q417465 wikiPageExternalLink RM%20Scope_B12%20-%2053-19-0_EN.pdf.
- Q417465 wikiPageExternalLink wqjmv74186x57wx1.
- Q417465 wikiPageWikiLink Q127076.
- Q417465 wikiPageWikiLink Q1367466.
- Q417465 wikiPageWikiLink Q144.
- Q417465 wikiPageWikiLink Q156871.
- Q417465 wikiPageWikiLink Q163648.
- Q417465 wikiPageWikiLink Q186889.
- Q417465 wikiPageWikiLink Q1947304.
- Q417465 wikiPageWikiLink Q219102.
- Q417465 wikiPageWikiLink Q2507454.
- Q417465 wikiPageWikiLink Q254327.
- Q417465 wikiPageWikiLink Q266423.
- Q417465 wikiPageWikiLink Q339221.
- Q417465 wikiPageWikiLink Q40878.
- Q417465 wikiPageWikiLink Q417682.
- Q417465 wikiPageWikiLink Q467717.
- Q417465 wikiPageWikiLink Q492.
- Q417465 wikiPageWikiLink Q496812.
- Q417465 wikiPageWikiLink Q653197.
- Q417465 wikiPageWikiLink Q683498.
- Q417465 wikiPageWikiLink Q7297892.
- Q417465 wikiPageWikiLink Q8805811.
- Q417465 wikiPageWikiLink Q9052781.
- Q417465 wikiPageWikiLink Q918285.
- Q417465 wikiPageWikiLink Q9458667.
- Q417465 atcPrefix "L01".
- Q417465 atcSuffix "XX23".
- Q417465 bioavailability "40.0".
- Q417465 casNumber "53".
- Q417465 drugbank "DB00648".
- Q417465 iupacName "-1".
- Q417465 pubchem "4211".
- Q417465 unii "780000".
- Q417465 type ChemicalSubstance.
- Q417465 type Drug.
- Q417465 type ChemicalObject.
- Q417465 type Thing.
- Q417465 type Q8386.
- Q417465 comment "Mitotane, also known as o,p'-DDD (Lysodren), is an antineoplastic medication used in the treatment of adrenocortical carcinoma. It is an isomer of DDD and is a derivative of DDT. Its main use is in those patients who have persistent disease despite surgical resection, those who are not surgical candidates, or those who have metastatic disease. It has been produced by Bristol Myers Squibb SpA but it is marketed as an orphan drug due to the small number of patients in need of it.".
- Q417465 label "Mitotane".
- Q417465 depiction Mitotane.svg.