DBpedia 2016-04

Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q415336> ?p ?o }

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Q415336 subject Q7214245.
Q415336 subject Q8106593.
Q415336 subject Q8672733.
Q415336 abstract "Minocycline (INN) is a broad-spectrum tetracycline antibiotic, and has a broader spectrum than the other members of the group. It is a bacteriostatic antibiotic, classified as a long-acting type. As a result of its long half-life it generally has serum levels 2–4 times that of the simple water-soluble tetracyclines (150 mg giving 16 times the activity levels compared with 250 mg of tetracycline at 24–48 hours).Minocycline is the most lipid-soluble of the tetracycline-class antibiotics, giving it the greatest penetration into the prostate and brain, but also the greatest amount of central nervous system (CNS)-related side effects, such as vertigo. A common side effect is diarrhea. Uncommon side effects (with prolonged therapy) include skin discolouration and autoimmune disorders that are not seen with other drugs in the class.Minocycline is a relatively poor tetracycline-class antibiotic choice for urinary pathogens sensitive to this antibiotic class, as its solubility in water and levels in the urine are less than all other tetracyclines. Minocycline is metabolized by the liver and has poor urinary excretion.Minocycline is not a naturally-occurring antibiotic, but was synthesized semi-synthetically from natural tetracycline antibiotics by Lederle Laboratories in 1966, and marketed by them under the brand name Minocin.".
Q415336 atcPrefix "J01".
Q415336 atcSuffix "AA08".
Q415336 bioavailability "100.0".
Q415336 casNumber "10118-90-8".
Q415336 chEBI "50694".
Q415336 drugbank "DB01017".
Q415336 fdaUniiCode "FYY3R43WGO".
Q415336 iupacName "(2E,4S,4aR,5aS,12aR)- 2-(amino-hydroxy-methylidene)- 4,7-bis(dimethylamino)- 10,11,12a-trihydroxy-4a,5,5a,6- tetrahydro-4H-tetracene- 1,3,12-trione".
Q415336 pubchem "24960".
Q415336 thumbnail Minocycline_structure.svg?width=300.
Q415336 wikiPageExternalLink NCT00409747.
Q415336 wikiPageExternalLink minocycline.html.
Q415336 wikiPageExternalLink article.htm.
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