Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q4132745> ?p ?o }
Showing triples 1 to 48 of
48
with 100 triples per page.
- Q4132745 subject Q5920511.
- Q4132745 subject Q7334131.
- Q4132745 subject Q7482068.
- Q4132745 subject Q7486806.
- Q4132745 subject Q7579524.
- Q4132745 subject Q8616358.
- Q4132745 subject Q8789452.
- Q4132745 subject Q8919936.
- Q4132745 abstract "Halofuginone is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa febrifuga (Chang Shan). Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S. Food and Drug Administration.Halofuginone inhibits the development of T helper 17 cells, immune cells that play an important role in autoimmune disease, but it does not affect other kinds of T cells which are involved in normal immune function. Halofuginone therefore has potential for the treatment of autoimmune disorders.Halofuginone is also an inhibitor of collagen type I gene expression and as a consequence it may inhibit tumor cell growth.Halofuginone exerts its effects by acting as a high affinity inhibitor of the enzyme Glutamyl-Prolyl tRNA synthetase. Inhibition of prolyl tRNA charging leads to the accumulation of uncharged prolyl tRNAs, which serve as a signal to initiate the amino acid starvation response, which in turn exerts anti-inflammatory and anti-fibrotic effects.".
- Q4132745 atcPrefix "P51".
- Q4132745 atcSuffix "AX08".
- Q4132745 casNumber "55837-20-2".
- Q4132745 fdaUniiCode "L31MM1385E".
- Q4132745 iupacName "7-Bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4-quinazolinone".
- Q4132745 pubchem "400772".
- Q4132745 thumbnail Halofuginone2DACS.svg?width=300.
- Q4132745 wikiPageWikiLink Q1100840.
- Q4132745 wikiPageWikiLink Q1367466.
- Q4132745 wikiPageWikiLink Q19605.
- Q4132745 wikiPageWikiLink Q2013529.
- Q4132745 wikiPageWikiLink Q204711.
- Q4132745 wikiPageWikiLink Q5139155.
- Q4132745 wikiPageWikiLink Q5413935.
- Q4132745 wikiPageWikiLink Q5920511.
- Q4132745 wikiPageWikiLink Q7334131.
- Q4132745 wikiPageWikiLink Q7482068.
- Q4132745 wikiPageWikiLink Q7486806.
- Q4132745 wikiPageWikiLink Q7579524.
- Q4132745 wikiPageWikiLink Q768227.
- Q4132745 wikiPageWikiLink Q7860612.
- Q4132745 wikiPageWikiLink Q8616358.
- Q4132745 wikiPageWikiLink Q8789452.
- Q4132745 wikiPageWikiLink Q8919936.
- Q4132745 wikiPageWikiLink Q958797.
- Q4132745 atcPrefix "P51".
- Q4132745 atcSuffix "AX08".
- Q4132745 casNumber "55837".
- Q4132745 iupacName "7".
- Q4132745 pubchem "400772".
- Q4132745 unii "L31MM1385E".
- Q4132745 type ChemicalSubstance.
- Q4132745 type Drug.
- Q4132745 type ChemicalObject.
- Q4132745 type Thing.
- Q4132745 type Q8386.
- Q4132745 comment "Halofuginone is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa febrifuga (Chang Shan). Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S.".
- Q4132745 label "Halofuginone".
- Q4132745 depiction Halofuginone2DACS.svg.