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- Q409595 subject Q6870315.
- Q409595 subject Q7469560.
- Q409595 subject Q8529178.
- Q409595 abstract "Isocarboxazid (Marplan, Marplon, Enerzer) is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class used as an antidepressant. Along with phenelzine and tranylcypromine, it is one of only three classical MAOIs still available for clinical use in the treatment of psychiatric disorders in the United States, though it is not as commonly employed in comparison to the others.Isocarboxazid is primarily used to treat mood and anxiety disorders. It has also been investigated in the treatment of Parkinson's disease and other dementia-related disorders. Although efficacious, isocarboxazid produces many side effects, which may include headaches, jaundice, chest pain, weight gain, orthostatic hypotension, fainting, dizziness, and tremors. Isocarboxazid, as well as other MAOIs, increase the levels of the monoamine neurotransmitters serotonin, dopamine, and norepinephrine in the brain.Classical MAOIs, including isocarboxazid, are used only very rarely in the present day due to prominent food and drug interactions and have been largely superseded by newer, safer, and more tolerable antidepressants such as the selective serotonin reuptake inhibitors (SSRIs). The cause of the interactions is because MAOIs inhibit the metabolism of dietary amines (e.g., tyramine) and the monoamine neurotransmitters. In combination with other drugs that increase the levels of the monoamine neurotransmitters such as the SSRIs, or with certain foods high in dietary amines such as aged cheeses, MAOIs can produce dangerous elevations of monoamine neurotransmitters resulting in potentially life-threatening syndromes such as hypertensive crisis and serotonin syndrome.".
- Q409595 atcPrefix "N06".
- Q409595 atcSuffix "AF01".
- Q409595 casNumber "59-63-2".
- Q409595 drugbank "DB01247".
- Q409595 fdaUniiCode "34237V843T".
- Q409595 iupacName "N′-benzyl-5-methylisoxazole-3-carbohydrazide".
- Q409595 pubchem "3759".
- Q409595 thumbnail Isocarboxazid_structure.svg?width=300.
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- Q409595 wikiPageWikiLink Q6870315.
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- Q409595 wikiPageWikiLink Q7469560.
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- Q409595 wikiPageWikiLink Q8529178.
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- Q409595 atcPrefix "N06".
- Q409595 atcSuffix "AF01".
- Q409595 casNumber "59".
- Q409595 drugbank "DB01247".
- Q409595 iupacName "N′-benzyl-5-methylisoxazole-3-carbohydrazide".
- Q409595 pubchem "3759".
- Q409595 unii "34237".
- Q409595 type ChemicalSubstance.
- Q409595 type Drug.
- Q409595 type ChemicalObject.
- Q409595 type Thing.
- Q409595 type Q8386.
- Q409595 comment "Isocarboxazid (Marplan, Marplon, Enerzer) is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class used as an antidepressant. Along with phenelzine and tranylcypromine, it is one of only three classical MAOIs still available for clinical use in the treatment of psychiatric disorders in the United States, though it is not as commonly employed in comparison to the others.Isocarboxazid is primarily used to treat mood and anxiety disorders.".
- Q409595 label "Isocarboxazid".
- Q409595 depiction Isocarboxazid_structure.svg.