DBpedia – Linked Data Fragments

Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q407541> ?p ?o }

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• Q407541 subject Q9134654.
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• Q407541 abstract "Fentanyl (also known as fentanil, brand names Sublimaze, Actiq, Durogesic, Duragesic, Fentora, Matrifen, Haldid, Onsolis, Instanyl, Abstral, Lazanda and others) is a potent, synthetic opioid analgesic with a rapid onset and short duration of action. It is a strong agonist at the μ-opioid receptors. Historically, it has been used to treat breakthrough pain and is commonly used in pre-procedures as a pain reliever as well as an anesthetic in combination with a benzodiazepine.Fentanyl is approximately 80 to 100 times more potent than morphine and roughly 40 to 50 times more potent than pharmaceutical grade (100% pure) heroin.Fentanyl was first synthesized by Paul Janssen in 1960, following the medical inception of pethidine (also known as meperidine, marketed as Demerol) several years earlier. Janssen developed fentanyl by assaying analogues of the structurally related drug pethidine for opioid activity. The widespread use of fentanyl triggered the production of fentanyl citrate (the salt formed by combining fentanyl and citric acid in a 1:1 stoichiometry), which entered the clinical practice as a general anaesthetic under the trade name Sublimaze in the 1960s. Following this, many other fentanyl analogues were developed and introduced into medical practice, including sufentanil, alfentanil, remifentanil, and lofentanil.In the mid-1990s, fentanyl was first introduced for widespread palliative use with the clinical introduction of the Duragesic patch, followed in the next decade by the introduction of the first quick-acting prescription formulations of fentanyl for personal use, the Actiq lollipop and Fentora buccal as well as through the delivery method of estradiol Mylan transdermal patches. As of 2012 fentanyl was the most widely used synthetic opioid in clinical practice, with several new delivery methods now available, including a sublingual spray for cancer patients. In 2013, 1700 kilograms were used globally.Fentanyl is used recreationally, whereby death is common. Deaths have resulted from both recreational and improper medical use.".
• Q407541 atcPrefix "N01".
• Q407541 atcSuffix "AH01".
• Q407541 bioavailability "33.0".
• Q407541 bioavailability "50.0".
• Q407541 bioavailability "89.0".
• Q407541 bioavailability "92.0".
• Q407541 casNumber "437-38-7".
• Q407541 chEBI "119915".
• Q407541 drugbank "DB00813".
• Q407541 fdaUniiCode "UF599785JZ".
• Q407541 iupacName "N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylpropanamide".
• Q407541 pubchem "3345".
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