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- Q3836670 subject Q8543773.
- Q3836670 subject Q8805811.
- Q3836670 abstract "Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the mitochondrially bound hexokinase. Later studies in Ehrlich ascites tumor cells showed that lonidamine inhibits both respiration and glycolysis leading to a decrease in cellular ATP.Clinical trials of lonidamine in combination with other anticancer agents for a variety of cancers has begun. This is due to its proven ability to inhibit energy metabolism in cancer cells, and to enhance the activity of anticancer agents.Lonidamine has been used in the treatment of brain tumours in combination with radiotherapy and temozolomide. Results showed that a combination of temozolomide and lonidamine at clinically achievable, low plasma concentrations, could inhibit tumour growth, and lonidamine could reduce the dose of temozolomide required for radiosensitization of brain tumours.A derivative of lonidamine, gamendazole, is in testing as a possible male contraceptive pill.".
- Q3836670 atcPrefix "L01".
- Q3836670 atcSuffix "XX07".
- Q3836670 casNumber "50264-69-2".
- Q3836670 fdaUniiCode "U78804BIDR".
- Q3836670 iupacName "1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid".
- Q3836670 pubchem "39562".
- Q3836670 thumbnail Lonidamine.svg?width=300.
- Q3836670 wikiPageWikiLink Q162643.
- Q3836670 wikiPageWikiLink Q3344800.
- Q3836670 wikiPageWikiLink Q5520039.
- Q3836670 wikiPageWikiLink Q8543773.
- Q3836670 wikiPageWikiLink Q8805811.
- Q3836670 wikiPageWikiLink Q982914.
- Q3836670 atcPrefix "L01".
- Q3836670 atcSuffix "XX07".
- Q3836670 casNumber "50264".
- Q3836670 iupacName "1".
- Q3836670 pubchem "39562".
- Q3836670 unii "U78804BIDR".
- Q3836670 type ChemicalSubstance.
- Q3836670 type Drug.
- Q3836670 type ChemicalObject.
- Q3836670 type Thing.
- Q3836670 type Q8386.
- Q3836670 comment "Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the mitochondrially bound hexokinase.".
- Q3836670 label "Lonidamine".
- Q3836670 depiction Lonidamine.svg.