Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q3678806> ?p ?o }
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- Q3678806 subject Q7211373.
- Q3678806 abstract "Cixutumumab is a monoclonal antibody for the treatment of solid tumors.This drug was developed by ImClone Systems Inc. under the name IMC-A12.It is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R) with potential antineoplastic activity. Cixutumumab selectively binds to membrane-bound IGF-1R, thereby preventing the binding of the natural ligand IGF-1 and the subsequent activation of PI3K/AKT signaling pathway. Downregulation of the PI3K/AKT survival pathway may result in the induction of cancer cell apoptosis and may decrease cancer cellular proliferation. IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed by many cancer cell types, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been implicated in tumorigenesis and metastasis.".
- Q3678806 atcPrefix "none".
- Q3678806 casNumber "947687-12-9".
- Q3678806 fdaUniiCode "2285XW22DR".
- Q3678806 wikiPageWikiLink Q14901457.
- Q3678806 wikiPageWikiLink Q422248.
- Q3678806 wikiPageWikiLink Q6001772.
- Q3678806 wikiPageWikiLink Q7211373.
- Q3678806 atcPrefix "none".
- Q3678806 casNumber "947687".
- Q3678806 unii "2285".
- Q3678806 type ChemicalSubstance.
- Q3678806 type Drug.
- Q3678806 type ChemicalObject.
- Q3678806 type Thing.
- Q3678806 type Q8386.
- Q3678806 comment "Cixutumumab is a monoclonal antibody for the treatment of solid tumors.This drug was developed by ImClone Systems Inc. under the name IMC-A12.It is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R) with potential antineoplastic activity. Cixutumumab selectively binds to membrane-bound IGF-1R, thereby preventing the binding of the natural ligand IGF-1 and the subsequent activation of PI3K/AKT signaling pathway.".
- Q3678806 label "Cixutumumab".