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- Q3611058 subject Q18924462.
- Q3611058 subject Q20870732.
- Q3611058 subject Q5920511.
- Q3611058 subject Q7145146.
- Q3611058 subject Q7579524.
- Q3611058 subject Q9586229.
- Q3611058 abstract "Alfaxalone (INN, JAN), also known as alphaxalone or alphaxolone (BAN), is a neuroactive steroid and general anaesthetic. It is used in veterinary practice under the trade name Alfaxan, and is licensed for use in both dogs and cats. Along with alfadolone, it is also one of the constituents of anesthetic drug mixture althesin.Unlike some of its predecessors alfaxalone is not associated with histamine release and anaphylaxis.A study 1987 found the primary mechanism for the anaesthetic action of alfaxalone to be modulation of neuronal cell membrane chloride ion transport, induced by binding of alfaxalone to GABAA cell surface receptors.A 1994 study found that alfaxalone binds to a different region of this receptor than the benzodiazepines.. These benzodiazepine-insensitive GABAA receptors are located extrasynaptically and are responsible for tonic inhibition. The occurrence of tonic GABAA inhibition coincides with the expression of relatively rare receptor subunits, particularly the α4, α6, and δ subunits, and as a rule of thumb, δ subunit-containing receptors are extrasynaptic.Alfaxalone is metabolised rapidly in the liver. It has a very short plasma elimination half-life in dogs and cats.".
- Q3611058 atcPrefix "N01".
- Q3611058 atcSuffix "AX05".
- Q3611058 casNumber "23930-19-0".
- Q3611058 fdaUniiCode "BD07M97B2A".
- Q3611058 iupacName "3α-hydroxy-5α-pregnane-11,20-dione".
- Q3611058 pubchem "104845".
- Q3611058 thumbnail Alphaxolone.svg?width=300.
- Q3611058 wikiPageWikiLink Q1779868.
- Q3611058 wikiPageWikiLink Q18344323.
- Q3611058 wikiPageWikiLink Q18394005.
- Q3611058 wikiPageWikiLink Q18924462.
- Q3611058 wikiPageWikiLink Q20870732.
- Q3611058 wikiPageWikiLink Q2659374.
- Q3611058 wikiPageWikiLink Q2755101.
- Q3611058 wikiPageWikiLink Q3758034.
- Q3611058 wikiPageWikiLink Q3792004.
- Q3611058 wikiPageWikiLink Q4721853.
- Q3611058 wikiPageWikiLink Q4721889.
- Q3611058 wikiPageWikiLink Q5920511.
- Q3611058 wikiPageWikiLink Q60147.
- Q3611058 wikiPageWikiLink Q6158099.
- Q3611058 wikiPageWikiLink Q6863285.
- Q3611058 wikiPageWikiLink Q7145146.
- Q3611058 wikiPageWikiLink Q7579524.
- Q3611058 wikiPageWikiLink Q824258.
- Q3611058 wikiPageWikiLink Q83871.
- Q3611058 wikiPageWikiLink Q918753.
- Q3611058 wikiPageWikiLink Q9586229.
- Q3611058 atcPrefix "N01".
- Q3611058 atcSuffix "AX05".
- Q3611058 casNumber "23930".
- Q3611058 iupacName "3".
- Q3611058 pubchem "104845".
- Q3611058 unii "BD07M97B2A".
- Q3611058 type ChemicalSubstance.
- Q3611058 type Drug.
- Q3611058 type ChemicalObject.
- Q3611058 type Thing.
- Q3611058 type Q8386.
- Q3611058 comment "Alfaxalone (INN, JAN), also known as alphaxalone or alphaxolone (BAN), is a neuroactive steroid and general anaesthetic. It is used in veterinary practice under the trade name Alfaxan, and is licensed for use in both dogs and cats.".
- Q3611058 label "Alfaxalone".
- Q3611058 depiction Alphaxolone.svg.