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- Q3599051 subject Q8420574.
- Q3599051 abstract "4-Hydroxycoumarins belong to a class of vitamin K antagonist (VKA) anticoagulant drug molecules derived from coumarin by adding a hydroxy group at the 4 position to obtain 4-hydroxycoumarin, then adding a large aromatic substituent at the 3-position (the ring-carbon between the hydroxyl and the carbonyl). The large 3-position substituent is required for anticoagulant activity.The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase. These compounds are not direct antagonists (in the pharmaceutical sense) of vitamin K, but rather act to deplete reduced vitamin K in tissues. For this reason vitamin K antagonizes their effect, and this has led to the loose terminology of vitamin K antagonism.".
- Q3599051 thumbnail Rattenvergifwaarschuwing_edit.JPG?width=300.
- Q3599051 wikiPageExternalLink 667.shtm.
- Q3599051 wikiPageWikiLink Q104116.
- Q3599051 wikiPageWikiLink Q111812.
- Q3599051 wikiPageWikiLink Q161142.
- Q3599051 wikiPageWikiLink Q161210.
- Q3599051 wikiPageWikiLink Q182338.
- Q3599051 wikiPageWikiLink Q19720126.
- Q3599051 wikiPageWikiLink Q210390.
- Q3599051 wikiPageWikiLink Q215118.
- Q3599051 wikiPageWikiLink Q2333757.
- Q3599051 wikiPageWikiLink Q267896.
- Q3599051 wikiPageWikiLink Q2852541.
- Q3599051 wikiPageWikiLink Q304088.
- Q3599051 wikiPageWikiLink Q3991659.
- Q3599051 wikiPageWikiLink Q4014990.
- Q3599051 wikiPageWikiLink Q407431.
- Q3599051 wikiPageWikiLink Q408221.
- Q3599051 wikiPageWikiLink Q415772.
- Q3599051 wikiPageWikiLink Q420886.
- Q3599051 wikiPageWikiLink Q421203.
- Q3599051 wikiPageWikiLink Q422449.
- Q3599051 wikiPageWikiLink Q423091.
- Q3599051 wikiPageWikiLink Q424775.
- Q3599051 wikiPageWikiLink Q426269.
- Q3599051 wikiPageWikiLink Q706.
- Q3599051 wikiPageWikiLink Q8420574.
- Q3599051 wikiPageWikiLink Q924146.
- Q3599051 comment "4-Hydroxycoumarins belong to a class of vitamin K antagonist (VKA) anticoagulant drug molecules derived from coumarin by adding a hydroxy group at the 4 position to obtain 4-hydroxycoumarin, then adding a large aromatic substituent at the 3-position (the ring-carbon between the hydroxyl and the carbonyl). The large 3-position substituent is required for anticoagulant activity.The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase.".
- Q3599051 label "4-Hydroxycoumarins".
- Q3599051 depiction Rattenvergifwaarschuwing_edit.JPG.