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- Q3552104 subject Q4925926.
- Q3552104 abstract "An upstream activating sequence or upstream activation sequence (UAS) is a cis-acting regulatory sequence. It is distinct from the promoter and increases the expression of a neighbouring gene. Due to its essential role in activating transcription, the upstream activating sequence is often considered to be analogous to the function of the enhancer in multicellular eukaryotes. Upstream activation sequences are a crucial part of induction, enhancing the expression of the protein of interest through increased transcriptional activity. The upstream activation sequence is found adjacently upstream to a minimal promoter (TATA box) and serves as a binding site for transactivators. If the transcriptional transactivator does not bind to the UAS in the proper orientation then transcription cannot begin. To further understand the function of an upstream activation sequence, it is beneficial to see its role in the cascade of events that lead to transcription activation. The pathway begins when activators bind to their target at the UAS recruiting a mediator. A TATA-binding protein subunit of a transcription factor then binds to the TATA box, recruiting additional transcription factors. The mediator then recruits RNA polymerase II to the pre-initiation complex. Once initiated, RNA polymerase II is released from the complex and transcription begins.".
- Q3552104 wikiPageExternalLink 174603.html.
- Q3552104 wikiPageExternalLink 851592.html.
- Q3552104 wikiPageExternalLink 852307.html.
- Q3552104 wikiPageWikiLink Q1093165.
- Q3552104 wikiPageWikiLink Q1295754.
- Q3552104 wikiPageWikiLink Q1413955.
- Q3552104 wikiPageWikiLink Q177900.
- Q3552104 wikiPageWikiLink Q224093.
- Q3552104 wikiPageWikiLink Q3647148.
- Q3552104 wikiPageWikiLink Q377955.
- Q3552104 wikiPageWikiLink Q3817769.
- Q3552104 wikiPageWikiLink Q407384.
- Q3552104 wikiPageWikiLink Q425326.
- Q3552104 wikiPageWikiLink Q4925926.
- Q3552104 wikiPageWikiLink Q589420.
- Q3552104 wikiPageWikiLink Q7187.
- Q3552104 wikiPageWikiLink Q719725.
- Q3552104 wikiPageWikiLink Q913367.
- Q3552104 comment "An upstream activating sequence or upstream activation sequence (UAS) is a cis-acting regulatory sequence. It is distinct from the promoter and increases the expression of a neighbouring gene. Due to its essential role in activating transcription, the upstream activating sequence is often considered to be analogous to the function of the enhancer in multicellular eukaryotes.".
- Q3552104 label "Upstream activating sequence".