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- Q3491837 subject Q7091330.
- Q3491837 abstract "Proinflammatory cytokines are a specific category of cytokines that are important in cell signaling and promotes systemic inflammation. They are produced predominantly by activated macrophages and are involved in the up-regulation of inflammatory reactions. In contrast to anti-inflammatory cytokines, which promote healing and reduce inflammation, proinflammatory cytokines act to make a disease worse. Functions include neutralizing antibodies, serving as soluble receptors and receptor antagonists, and inhibiting proteases. Proinflammatory cytokines arise from genes that code for the translation of small mediator molecules that induce a response after upregulation. For example, chemokines are a class of genes that are proinflammatory. IL-1, TNF alpha, and chemokines are examples of proinflammatory cytokines.Proinflammatory cytokines work with other important molecules from the immune system, such as neutrophils and leukocytes, in generating an immune response. This proinflammatory cytokine-mediated inflammation generates a collection of gene products in response to a trigger that notices a foreign body. However, excessive amounts of proinflammatory cytokines have been shown to cause detrimental effects, causing chronic systemic elevations in the body. A lack of regulation in the release of these cytokines has been linked to different diseases, such as atherosclerosis and cancers. There are further implications that misregulation of proinflammatory cytokines is also linked to depression and other neurologically related effects to the body[3]. Aging and exercise also play a role in the amount of inflammation produced through the release of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-α). Recent therapies blocking proinflammatory cytokines in order to prevent the attack of these cytokines against our own bodies.It is important that the regulation between proinflammatory and anti-inflammatory cytokines stay balanced, as that could alter one's susceptibility to a disease.".
- Q3491837 wikiPageWikiLink Q101991.
- Q3491837 wikiPageWikiLink Q1194520.
- Q3491837 wikiPageWikiLink Q12252367.
- Q3491837 wikiPageWikiLink Q14864464.
- Q3491837 wikiPageWikiLink Q14865236.
- Q3491837 wikiPageWikiLink Q14916410.
- Q3491837 wikiPageWikiLink Q178061.
- Q3491837 wikiPageWikiLink Q178194.
- Q3491837 wikiPageWikiLink Q18032037.
- Q3491837 wikiPageWikiLink Q188417.
- Q3491837 wikiPageWikiLink Q235342.
- Q3491837 wikiPageWikiLink Q3569101.
- Q3491837 wikiPageWikiLink Q38933.
- Q3491837 wikiPageWikiLink Q4.
- Q3491837 wikiPageWikiLink Q42395.
- Q3491837 wikiPageWikiLink Q58184.
- Q3491837 wikiPageWikiLink Q703.
- Q3491837 wikiPageWikiLink Q7091330.
- Q3491837 wikiPageWikiLink Q917447.
- Q3491837 comment "Proinflammatory cytokines are a specific category of cytokines that are important in cell signaling and promotes systemic inflammation. They are produced predominantly by activated macrophages and are involved in the up-regulation of inflammatory reactions. In contrast to anti-inflammatory cytokines, which promote healing and reduce inflammation, proinflammatory cytokines act to make a disease worse.".
- Q3491837 label "Proinflammatory cytokine".