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- Q3378713 subject Q8256381.
- Q3378713 subject Q8879081.
- Q3378713 subject Q9536267.
- Q3378713 abstract "The combination of the drugs phentermine and topiramate extended-release (ER) (trade name Qsymia kyoo-sim-EE-uh) is a medication used for weight loss. In clinical trials, phentermine/topiramate ER was associated with modest but statistically significant weight loss when compared with placebo. This weight loss was associated with improvements in weight-related comorbidities such as improved glycemia, decreased blood pressure, and improved cholesterol.Phentermine/topiramate ER was developed by Vivus, Inc., a California pharmaceutical company. Phentermine is a sympathomimetic amine which acts as an appetite suppressant and stimulant. Topiramate is an anticonvulsant that has weight loss side effects. The exact mechanism of action for both drugs is unknown.In 2012 the U.S. Food and Drug Administration approved phentermine/topiramate ER as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of at least 30 kg/m², or at least 27 kg/m² (overweight) in the presence of at least one weight-related comorbidity such as hypertension, type 2 diabetes mellitus, or dyslipidemia. Phentermine/topiramate ER is available in certified retail pharmacies nationwide and also available through a certified mail-order pharmacy network. Approval was denied by European regulatory authorities, who cited potential risk to the heart and blood vessels, psychiatric side effects, and cognitive side effects in explaining their decision.".
- Q3378713 atcPrefix "none".
- Q3378713 pubchem "56842108".
- Q3378713 thumbnail Phentermine_and_topiramate.svg?width=300.
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- Q3378713 atcPrefix "none".
- Q3378713 pubchem "56842108".
- Q3378713 type ChemicalSubstance.
- Q3378713 type Drug.
- Q3378713 type ChemicalObject.
- Q3378713 type Thing.
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- Q3378713 comment "The combination of the drugs phentermine and topiramate extended-release (ER) (trade name Qsymia kyoo-sim-EE-uh) is a medication used for weight loss. In clinical trials, phentermine/topiramate ER was associated with modest but statistically significant weight loss when compared with placebo.".
- Q3378713 label "Phentermine/topiramate".
- Q3378713 depiction Phentermine_and_topiramate.svg.