Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q32089> ?p ?o }
- Q32089 subject Q7211328.
- Q32089 subject Q7486806.
- Q32089 subject Q8593033.
- Q32089 subject Q8654892.
- Q32089 subject Q9785517.
- Q32089 abstract "Sirolimus (INN/USAN), also known as rapamycin, is a macrolide (one of a group of drugs containing a macrolide ring) produced by the bacterium Streptomyces hygroscopicus. It has immunosuppressant functions in humans and is used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It prevents activation of T cells and B cells by inhibiting the production of interleukin-2 (IL-2). Sirolimus is also used as a coronary stent coating.Sirolimus was isolated for the first time in 1972 by Suren Sehgal and colleagues from samples of Streptomyces hygroscopicus found on Easter Island. The compound was originally named rapamycin after the native name of the island, Rapa Nui. Sirolimus was initially developed as an antifungal agent. However, this use was abandoned when it was discovered to have potent immunosuppressive and antiproliferative properties due to its ability to inhibit mTOR. It has since been shown to prolong the life of mice and might also be useful in the treatment of certain cancers. It was approved by the US Food and Drug Administration in September 1999 and is marketed under the trade name Rapamune by Pfizer (formerly by Wyeth).".
- Q32089 atcPrefix "L04".
- Q32089 atcSuffix "AA10".
- Q32089 bioavailability "14.0".
- Q32089 bioavailability "18.0".
- Q32089 casNumber "53123-88-9".
- Q32089 chEBI "9168".
- Q32089 drugbank "DB00877".
- Q32089 fdaUniiCode "W36ZG6FT64".
- Q32089 iupacName "(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,".
- Q32089 iupacName "(4H,6H,31H)-pentone".
- Q32089 iupacName "1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-".
- Q32089 iupacName "26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,".
- Q32089 iupacName "27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-".
- Q32089 iupacName "[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-".
- Q32089 iupacName "hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]-".
- Q32089 iupacName "oxaazacyclohentriacontine-1,5,11,28,29".
- Q32089 pubchem "5284616".
- Q32089 thumbnail Sirolimus.svg?width=300.
- Q32089 wikiPageExternalLink www.rapamune.com.
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