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- Q289013 subject Q6939104.
- Q289013 abstract "alpha-2-Macroglobulin, also known as α2-macroglobulin and abbreviated as α2M and A2M, is a large plasma protein found in the blood. It is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis.Alpha-2-Macroglobulin is the largest major nonimmunoglobulin protein in plasma. The alpha-2-macroglobulin molecule is synthesized mainly in liver, but also locally by macrophages, fibroblasts, and adrenocortical cells.Alpha 2 macroglobulin acts as an antiprotease and is able to inactivate an enormous variety of proteinases. It functions as an inhibitor of fibrinolysis by inhibiting plasmin and kallikrein. It functions as an inhibitor of coagulation by inhibiting thrombin. Alpha-2-macroglobulin may act as a carrier protein because it also binds to numerous growth factors and cytokines, such as platelet-derived growth factor, basic fibroblast growth factor, TGF-β, insulin, and IL-1β.No specific deficiency with associated disease has been recognized, and no disease state is attributed to low concentrations of alpha-2-macroglobulin.The concentration of alpha-2-macroglobulin rises 10-fold or more in the nephrotic syndrome when other lower molecular weight proteins are lost in the urine. The loss of alpha-2-macroglobulin into urine is prevented by its large size. The net result is that alpha-2-macroglobulin reaches serum levels equal to or greater than those of albumin in the nephrotic syndrome, which has the effect of maintaining oncotic pressure.".
- Q289013 arm "p".
- Q289013 band "13".
- Q289013 chromosome "12".
- Q289013 entrezgene "2".
- Q289013 hgncid "7".
- Q289013 locusSupplementaryData ".31".
- Q289013 omim "103950".
- Q289013 refseq "NM_000014".
- Q289013 symbol "A2M".
- Q289013 symbol "A2M_N".
- Q289013 symbol "A2M_N_2".
- Q289013 symbol "A2M_comp".
- Q289013 symbol "A2M_recep".
- Q289013 thumbnail 2P9R.png?width=300.
- Q289013 uniprot "P01023".
- Q289013 wikiPageExternalLink merops.cgi?id=I39.001.
- Q289013 wikiPageExternalLink explore.do?pdbId=2P9R.
- Q289013 wikiPageWikiLink Q101487.
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- Q289013 wikiPageWikiLink Q425402.
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- Q289013 wikiPageWikiLink Q6939104.
- Q289013 wikiPageWikiLink Q735188.
- Q289013 wikiPageWikiLink Q736715.
- Q289013 wikiPageWikiLink Q7873.
- Q289013 wikiPageWikiLink Q8054.
- Q289013 wikiPageWikiLink Q8066.
- Q289013 wikiPageWikiLink Q82264.
- Q289013 wikiPageWikiLink Q898238.
- Q289013 wikiPageWikiLink Q9368.
- Q289013 wikiPageWikiLink Q9377.
- Q289013 arm "p".
- Q289013 band "13".
- Q289013 chromosome "12".
- Q289013 entrezgene "2".
- Q289013 hgncid "7".
- Q289013 locussupplementarydata "0.31".
- Q289013 name "alpha-2-macroglobulin".
- Q289013 omim "103950".
- Q289013 refseq "NM_000014".
- Q289013 symbol "A2M".
- Q289013 symbol "A2M_N".
- Q289013 symbol "A2M_N_2".
- Q289013 symbol "A2M_comp".
- Q289013 symbol "A2M_recep".
- Q289013 uniprot "P01023".
- Q289013 type Biomolecule.
- Q289013 type Protein.
- Q289013 type Thing.
- Q289013 type Q206229.
- Q289013 type Q8054.
- Q289013 comment "alpha-2-Macroglobulin, also known as α2-macroglobulin and abbreviated as α2M and A2M, is a large plasma protein found in the blood. It is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis.Alpha-2-Macroglobulin is the largest major nonimmunoglobulin protein in plasma.".
- Q289013 label "Alpha-2-Macroglobulin".
- Q289013 depiction 2P9R.png.
- Q289013 name "alpha-2-macroglobulin".