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- Q275926 subject Q8297717.
- Q275926 subject Q8343736.
- Q275926 subject Q8661590.
- Q275926 subject Q8965786.
- Q275926 subject Q9454607.
- Q275926 abstract "Bumetanide (trade names Bumex or Burinex) is a loop diuretic of the sulfamyl category to treat heart failure. It is often used in people in whom high doses of furosemide are ineffective. It is marketed by Hoffmann-La Roche. The main difference between the two substances is in bioavailability and pharmacodynamic potency. Furosemide is incompletely absorbed in the intestine (60%), and there are substantial inter- and intraindividual differences in bioavailability (range 10-90%). Bumetanide is almost completely absorbed (80%), and the absorption is not altered when it is taken with food. It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect.Bumetanide is 40 times more potent than furosemide for patients with normal renal function.In the brain, bumetanide blocks the NKCC1 cation-chloride co-transporter, and thus decreases internal chloride concentration in neurons. In turn, this concentration change makes the action of GABA more hyperpolarizing, which may be useful for treatment of neonatal seizures, that quite often are not responsive to traditional GABA-targeted treatment, such as barbiturates. Bumetanide is therefore currently under evaluation as a prospective antiepileptic drug.".
- Q275926 atcPrefix "C03".
- Q275926 atcSuffix "CA02".
- Q275926 casNumber "28395-03-1".
- Q275926 chEBI "3213".
- Q275926 drugbank "DB00887".
- Q275926 fdaUniiCode "0Y2S3XUQ5H".
- Q275926 iupacName "3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid".
- Q275926 pubchem "2471".
- Q275926 thumbnail Bumetanide_structure.svg?width=300.
- Q275926 wikiPageExternalLink 018225s024lbl.pdf.
- Q275926 wikiPageWikiLink Q1154971.
- Q275926 wikiPageWikiLink Q1215884.
- Q275926 wikiPageWikiLink Q1542839.
- Q275926 wikiPageWikiLink Q181754.
- Q275926 wikiPageWikiLink Q204711.
- Q275926 wikiPageWikiLink Q206348.
- Q275926 wikiPageWikiLink Q210021.
- Q275926 wikiPageWikiLink Q212646.
- Q275926 wikiPageWikiLink Q2580288.
- Q275926 wikiPageWikiLink Q388801.
- Q275926 wikiPageWikiLink Q424280.
- Q275926 wikiPageWikiLink Q43054.
- Q275926 wikiPageWikiLink Q432083.
- Q275926 wikiPageWikiLink Q461809.
- Q275926 wikiPageWikiLink Q6279182.
- Q275926 wikiPageWikiLink Q640448.
- Q275926 wikiPageWikiLink Q718113.
- Q275926 wikiPageWikiLink Q8297717.
- Q275926 wikiPageWikiLink Q8343736.
- Q275926 wikiPageWikiLink Q8661590.
- Q275926 wikiPageWikiLink Q8965786.
- Q275926 wikiPageWikiLink Q912807.
- Q275926 wikiPageWikiLink Q9454607.
- Q275926 wikiPageWikiLink Q998.
- Q275926 atcPrefix "3.0".
- Q275926 atcSuffix "CA02".
- Q275926 casNumber "28395".
- Q275926 chebi "3213".
- Q275926 drugbank "DB00887".
- Q275926 iupacName "3".
- Q275926 pubchem "2471".
- Q275926 unii "0".
- Q275926 type ChemicalSubstance.
- Q275926 type Drug.
- Q275926 type ChemicalObject.
- Q275926 type Thing.
- Q275926 type Q8386.
- Q275926 comment "Bumetanide (trade names Bumex or Burinex) is a loop diuretic of the sulfamyl category to treat heart failure. It is often used in people in whom high doses of furosemide are ineffective. It is marketed by Hoffmann-La Roche. The main difference between the two substances is in bioavailability and pharmacodynamic potency. Furosemide is incompletely absorbed in the intestine (60%), and there are substantial inter- and intraindividual differences in bioavailability (range 10-90%).".
- Q275926 label "Bumetanide".
- Q275926 depiction Bumetanide_structure.svg.