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- Q2697833 subject Q7211328.
- Q2697833 subject Q8312632.
- Q2697833 subject Q8414607.
- Q2697833 abstract "Abatacept (marketed as Orencia) is drug used to treat autoimmune diseases like rheumatoid arthritis, by interfering with the immune activity of T cells. It is a modified antibody. Abatacept is a fusion protein composed of the Fc region of the immunoglobulin IgG1 fused to the extracellular domain of CTLA-4. In order for a T cell to be activated and produce an immune response, an antigen presenting cell must present two signals to the T cell. One of those signals is the major histocompatibility complex (MHC), combined with the antigen, and the other signal is the CD80 or CD86 molecule (also known as B7-1 and B7-2). Abatacept binds to the CD80 and CD86 molecule, and prevents the second signal. Without the second signal, the T cell can't be activated. Abatacept was developed by Bristol-Myers Squibb and is licensed in the United States for the treatment of rheumatoid arthritis in the case of inadequate response to anti-TNFα therapy. Some doctors criticize its cost ($3,500 to $3,800 a month, like other biological drugs of its class) and its promotional marketing.".
- Q2697833 atcPrefix "L04".
- Q2697833 atcSuffix "AA24".
- Q2697833 casNumber "332348-12-6".
- Q2697833 drugbank "DB01281".
- Q2697833 fdaUniiCode "7D0YB67S97".
- Q2697833 wikiPageExternalLink en&t=634475600483187694.
- Q2697833 wikiPageExternalLink index.jsp?BV_UseBVCookie=Yes.
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- Q2697833 wikiPageWikiLink Q7211328.
- Q2697833 wikiPageWikiLink Q79448.
- Q2697833 wikiPageWikiLink Q79460.
- Q2697833 wikiPageWikiLink Q810254.
- Q2697833 wikiPageWikiLink Q8312632.
- Q2697833 wikiPageWikiLink Q8414607.
- Q2697833 atcPrefix "L04".
- Q2697833 atcSuffix "AA24".
- Q2697833 casNumber "332348".
- Q2697833 drugbank "DB01281".
- Q2697833 unii "7".
- Q2697833 type ChemicalSubstance.
- Q2697833 type Drug.
- Q2697833 type ChemicalObject.
- Q2697833 type Thing.
- Q2697833 type Q8386.
- Q2697833 comment "Abatacept (marketed as Orencia) is drug used to treat autoimmune diseases like rheumatoid arthritis, by interfering with the immune activity of T cells. It is a modified antibody. Abatacept is a fusion protein composed of the Fc region of the immunoglobulin IgG1 fused to the extracellular domain of CTLA-4. In order for a T cell to be activated and produce an immune response, an antigen presenting cell must present two signals to the T cell.".
- Q2697833 label "Abatacept".
- Q2697833 homepage index.jsp?BV_UseBVCookie=Yes.