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- Q2687512 subject Q6913060.
- Q2687512 abstract "Chandelier neurons or chandelier cells are a subset of GABA-ergic cortical interneurons. They are described as parvalbumin-containing and fast-spiking to distinguish them from other subtypes of GABAergic neurons, although more recent work has suggested that only a subset of chandelier cells test positive for parvalbumin by immunostaining. The name comes from the specific shape of their axon arbors, with the terminals forming distinct arrays called "cartridges". The cartridges are immunoreactive to an isoform of the GABA membrane transporter, GAT-1, and this serves as their identifying feature. GAT-1 is involved in the process of GABA reuptake into nerve terminals, thus helping to terminate its synaptic activity. Chandelier neurons synapse exclusively to the axon initial segment of pyramidal neurons, near the site where action potential is generated. It is believed that they provide inhibitory input to the pyramidal neurons, but there is data showing that in some circumstances the GABA from chandelier neurons could be excitatory. The axon cartridges formed by chandelier cells are one of the synapse types which show the most dramatic changes during normal adolescence, which could potentially be relevant to the adult onset of psychiatric disease. Furthering this link, in schizophrenia, scientists have observed changes in their form and functionality, such as 40% decrease in the axon terminal density.".
- Q2687512 thumbnail Mouse_Chandelier_Cell.jpeg?width=300.
- Q2687512 wikiPageExternalLink dn14655-how-chandelier-cells-light-up-human-thought.html?feedId=online-news_rss20.
- Q2687512 wikiPageExternalLink lewis.asp.
- Q2687512 wikiPageExternalLink develop_mb.htm.
- Q2687512 wikiPageExternalLink search.php?q=Chandelier%20Cell&t=data&s=cover&b=0&r=20.
- Q2687512 wikiPageWikiLink Q11695472.
- Q2687512 wikiPageWikiLink Q1500732.
- Q2687512 wikiPageWikiLink Q178999.
- Q2687512 wikiPageWikiLink Q18031535.
- Q2687512 wikiPageWikiLink Q194277.
- Q2687512 wikiPageWikiLink Q210021.
- Q2687512 wikiPageWikiLink Q2116409.
- Q2687512 wikiPageWikiLink Q2720322.
- Q2687512 wikiPageWikiLink Q41112.
- Q2687512 wikiPageWikiLink Q6913060.
- Q2687512 comment "Chandelier neurons or chandelier cells are a subset of GABA-ergic cortical interneurons. They are described as parvalbumin-containing and fast-spiking to distinguish them from other subtypes of GABAergic neurons, although more recent work has suggested that only a subset of chandelier cells test positive for parvalbumin by immunostaining. The name comes from the specific shape of their axon arbors, with the terminals forming distinct arrays called "cartridges".".
- Q2687512 label "Chandelier cell".
- Q2687512 depiction Mouse_Chandelier_Cell.jpeg.