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- Q256377 subject Q6802066.
- Q256377 subject Q7458901.
- Q256377 subject Q8509241.
- Q256377 abstract "The Hantzsch pyridine synthesis or Hantzsch dihydropyridine synthesis is a multi-component organic reaction between an aldehyde such as formaldehyde, 2 equivalents of a β-keto ester such as ethyl acetoacetate and a nitrogen donor such as ammonium acetate or ammonia. The initial reaction product is a dihydropyridine which can be oxidized in a subsequent step to a pyridine. The driving force for this second reaction step is aromatization. This reaction was reported in 1881 by Arthur Rudolf Hantzsch. A 1,4-dihydropyridine dicarboxylate is also called a 1,4-DHP compound or a Hantzsch compound. These compounds are an important class of calcium channel blockers and as such commercialized in for instance nifedipine, amlodipine or nimodipine.The reaction has been demonstrated to proceed in water as reaction solvent and with direct aromatization by ferric chloride, Manganese Dioxide or potassium permanganate in a one-pot synthesis.The Hantzsch dihydropyridine synthesis is found to benefit from microwave chemistry.".
- Q256377 thumbnail Hantzsch_pyridine_synthesis.svg?width=300.
- Q256377 wikiPageWikiLink Q101497.
- Q256377 wikiPageWikiLink Q126328.
- Q256377 wikiPageWikiLink Q161210.
- Q256377 wikiPageWikiLink Q190865.
- Q256377 wikiPageWikiLink Q190901.
- Q256377 wikiPageWikiLink Q210385.
- Q256377 wikiPageWikiLink Q212527.
- Q256377 wikiPageWikiLink Q2161141.
- Q256377 wikiPageWikiLink Q230731.
- Q256377 wikiPageWikiLink Q3498942.
- Q256377 wikiPageWikiLink Q39111.
- Q256377 wikiPageWikiLink Q399771.
- Q256377 wikiPageWikiLink Q407674.
- Q256377 wikiPageWikiLink Q4087.
- Q256377 wikiPageWikiLink Q411347.
- Q256377 wikiPageWikiLink Q412074.
- Q256377 wikiPageWikiLink Q421429.
- Q256377 wikiPageWikiLink Q421700.
- Q256377 wikiPageWikiLink Q47192.
- Q256377 wikiPageWikiLink Q648191.
- Q256377 wikiPageWikiLink Q6802066.
- Q256377 wikiPageWikiLink Q69483.
- Q256377 wikiPageWikiLink Q7458901.
- Q256377 wikiPageWikiLink Q8509241.
- Q256377 wikiPageWikiLink Q903091.
- Q256377 wikiPageWikiLink Q905377.
- Q256377 comment "The Hantzsch pyridine synthesis or Hantzsch dihydropyridine synthesis is a multi-component organic reaction between an aldehyde such as formaldehyde, 2 equivalents of a β-keto ester such as ethyl acetoacetate and a nitrogen donor such as ammonium acetate or ammonia. The initial reaction product is a dihydropyridine which can be oxidized in a subsequent step to a pyridine. The driving force for this second reaction step is aromatization.".
- Q256377 label "Hantzsch pyridine synthesis".
- Q256377 depiction Hantzsch_pyridine_synthesis.svg.