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- Q2284254 subject Q7214226.
- Q2284254 abstract "A proerythroblast (or rubriblast, or pronormoblast) is the earliest of four stages in development of the normoblast.In histology, it is very difficult to distinguish it from the other "-blast" cells (lymphoblast, myeloblast, monoblast, and megakaryoblast). The cytoplasm is blue in an H&E stain, indicating that it is basophilic.Proerythroblasts arise from the CFU-e (colony-forming unit erythroid) cells, and give rise to basophilic erythroblasts. In the mouse, proerythroblasts are large committed progenitors that express high levels of transferrin receptor (iron acquisition receptor), the erythropoietin receptor (EpoR), some c-Kit (stem cell factor receptor), and are Ter119 (cell surface molecule)-positive. Their proliferative capacity is more limited compared to the preceding stage, the CFU-e.In vivo, starting with the proerythroblast stage, erythroid cells undergo several more cell divisions while at the same time upregulating survival genes such as Bcl-xL, acquiring and storing large amounts of iron, ramping up the synthesis of hemoglobin and other erythroid genes (in large part a GATA-1 dependent process that is augmented by the EpoR signaling) and decreasing in cell size, eventually removing their nuclei and being released into the bloodstream as a reticulocyte.".
- Q2284254 thumbnail Proerythroblast.png?width=300.
- Q2284254 wikiPageExternalLink tsld020.htm.
- Q2284254 wikiPageExternalLink Medula%20osea%20hemopoiesis24.htm.
- Q2284254 wikiPageExternalLink nrbc14.html.
- Q2284254 wikiPageExternalLink sld015.htm.
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- Q2284254 wikiPageWikiLink Q7214226.
- Q2284254 wikiPageWikiLink Q79899.
- Q2284254 name "Proerythroblast".
- Q2284254 type AnatomicalStructure.
- Q2284254 type Thing.
- Q2284254 type Q4936952.
- Q2284254 comment "A proerythroblast (or rubriblast, or pronormoblast) is the earliest of four stages in development of the normoblast.In histology, it is very difficult to distinguish it from the other "-blast" cells (lymphoblast, myeloblast, monoblast, and megakaryoblast). The cytoplasm is blue in an H&E stain, indicating that it is basophilic.Proerythroblasts arise from the CFU-e (colony-forming unit erythroid) cells, and give rise to basophilic erythroblasts.".
- Q2284254 label "Proerythroblast".
- Q2284254 depiction Proerythroblast.png.
- Q2284254 name "Proerythroblast".