Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q2066956> ?p ?o }
Showing triples 1 to 20 of
20
with 100 triples per page.
- Q2066956 subject Q8760220.
- Q2066956 abstract "In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity. A highly potent drug (e.g., fentanyl, alprazolam, risperidone) evokes a larger response at low concentrations, while a drug of lower potency (codeine, diazepam, ziprasidone) evokes a small response at low concentrations. It is proportional to affinity and efficacy.Affinity is the ability of the drug to bind to a receptor. Efficacy is the relationship between receptor occupancy and the ability to initiate a response at the molecular, cellular, tissue or system level. The response is equal to the effect, or (E), and depends on both the drug binding and the drug-bound receptor then producing a response; thus, potency depends on both affinity and efficacy. The agonist, the ligand, drug or hormone that binds to the receptor and initiates the response is usually abbreviated A or D. Below a certain concentration of agonist ([A]), E is too low to measure but at higher concentrations it becomes appreciable and rises with increasing agonist concentration [A] until at sufficiently high concentrations it can no longer be increased by raising [A] and asymptotes to a maximum Emax. The Emax is the maximum possible effect for the agonist. The concentration of A at which E is 50% of Emax is termed the half maximal effective concentration and is abbreviated [A]50, or more commonly EC50. The term "potency" refers to the [A]50 value. The lower the [A]50, the less the concentration of a drug is required to produce 50% of maximum effect and the higher the potency.Higher potency does not necessarily mean more side effects.".
- Q2066956 thumbnail Potency_pharmacology.svg?width=300.
- Q2066956 wikiPageExternalLink formulating-high-potency-drugs.
- Q2066956 wikiPageWikiLink Q128406.
- Q2066956 wikiPageWikiLink Q17072363.
- Q2066956 wikiPageWikiLink Q17145461.
- Q2066956 wikiPageWikiLink Q174723.
- Q2066956 wikiPageWikiLink Q205517.
- Q2066956 wikiPageWikiLink Q210402.
- Q2066956 wikiPageWikiLink Q286136.
- Q2066956 wikiPageWikiLink Q319877.
- Q2066956 wikiPageWikiLink Q407541.
- Q2066956 wikiPageWikiLink Q412443.
- Q2066956 wikiPageWikiLink Q45959.
- Q2066956 wikiPageWikiLink Q8760220.
- Q2066956 wikiPageWikiLink Q898254.
- Q2066956 comment "In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity. A highly potent drug (e.g., fentanyl, alprazolam, risperidone) evokes a larger response at low concentrations, while a drug of lower potency (codeine, diazepam, ziprasidone) evokes a small response at low concentrations. It is proportional to affinity and efficacy.Affinity is the ability of the drug to bind to a receptor.".
- Q2066956 label "Potency (pharmacology)".
- Q2066956 depiction Potency_pharmacology.svg.