Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q2064915> ?p ?o }
Showing triples 1 to 36 of
36
with 100 triples per page.
- Q2064915 subject Q7162167.
- Q2064915 subject Q7243524.
- Q2064915 subject Q7461375.
- Q2064915 abstract "11-Deoxycortisol, also known as cortodoxone (INN, USAN, BAN), as well as 17-hydroxy-11-deoxycorticosterone, 17α,21-dihydroxyprogesterone, and cortexolone, is a glucocorticoid steroid hormone that can be oxygenated to cortisol (hydrocortisone). It was first synthesized by Tadeusz Reichstein, and has also been referred to as Reichstein's Substance.On April 5, 1952, biochemist Durey Peterson and microbiologist Herbert Murray at Upjohn published the first report of a breakthrough fermentation process for the microbial 11α-oxygenation of steroids (e.g. progesterone) in a single step by common molds of the order Mucorales.11α-oxygenation of cortodoxone produces 11α-hydrocortisone, which can be chemically oxidized to cortisone, or converted by further chemical steps to cortisol.Subsequent fermentation processes for the microbial 11β-oxygenation of steroids in a single step were developed that could convert cortodoxone directly to cortisol.Cortodoxone functions as a glucocorticoid, though is less potent than cortisol. It can be synthesized from 17-hydroxyprogesterone. In 11β-hydroxylase deficiency, cortodoxone levels increase dramatically, causing hypertension (as opposed to 21α-hydroxylase deficiency, in which patients have low blood pressure from a lack of mineralocorticoids).Cortodoxone can also be converted to androstenedione. This could explain, at least in part, the marked increase in androstenedione levels in 11β-hydroxylase deficiency.".
- Q2064915 iupacName "(8R,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one".
- Q2064915 thumbnail Cortodoxone.png?width=300.
- Q2064915 wikiPageWikiLink Q115490.
- Q2064915 wikiPageWikiLink Q141280.
- Q2064915 wikiPageWikiLink Q159341.
- Q2064915 wikiPageWikiLink Q16266700.
- Q2064915 wikiPageWikiLink Q175901.
- Q2064915 wikiPageWikiLink Q190875.
- Q2064915 wikiPageWikiLink Q26963.
- Q2064915 wikiPageWikiLink Q275419.
- Q2064915 wikiPageWikiLink Q2919046.
- Q2064915 wikiPageWikiLink Q3779582.
- Q2064915 wikiPageWikiLink Q422137.
- Q2064915 wikiPageWikiLink Q422549.
- Q2064915 wikiPageWikiLink Q423185.
- Q2064915 wikiPageWikiLink Q4926095.
- Q2064915 wikiPageWikiLink Q7162167.
- Q2064915 wikiPageWikiLink Q7243524.
- Q2064915 wikiPageWikiLink Q7461375.
- Q2064915 wikiPageWikiLink Q824258.
- Q2064915 wikiPageWikiLink Q845523.
- Q2064915 wikiPageWikiLink Q918753.
- Q2064915 wikiPageWikiLink Q948846.
- Q2064915 iupacname "-17".
- Q2064915 type ChemicalCompound.
- Q2064915 type ChemicalSubstance.
- Q2064915 type ChemicalObject.
- Q2064915 type Thing.
- Q2064915 type Q11173.
- Q2064915 comment "11-Deoxycortisol, also known as cortodoxone (INN, USAN, BAN), as well as 17-hydroxy-11-deoxycorticosterone, 17α,21-dihydroxyprogesterone, and cortexolone, is a glucocorticoid steroid hormone that can be oxygenated to cortisol (hydrocortisone).".
- Q2064915 label "Cortodoxone".
- Q2064915 depiction Cortodoxone.png.