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- Q1968369 subject Q4926419.
- Q1968369 abstract "Human accelerated regions (HARs), first described in August 2006, are a set of 49 segments of the human genome that are conserved throughout vertebrate evolution but are strikingly different in humans. They are named according to their degree of difference between humans and chimpanzees (HAR1 showing the largest degree of human-chimpanzee differences). Found by scanning through genomic databases of multiple species, some of these highly mutated areas may contribute to human-specific traits. Others may represent loss of function mutations, possibly due to the action of biased gene conversion rather than adaptive evolution.Several of the HARs encompass genes known to produce proteins important in neurodevelopment. HAR1 is an 106-base pair stretch found on the long arm of chromosome 20 overlapping with part of the RNA genes HAR1F and HAR1R. HAR1F is active in the developing human brain. The HAR1 sequence is found (and conserved) in chickens and chimpanzees but is not present in fish or frogs that have been studied. There are 18 base pair mutations different between humans and chimpanzees, far more than expected by its history of conservation.HAR2 includes HACNS1 a gene enhancer "that may have contributed to the evolution of the uniquely opposable human thumb, and possibly also modifications in the ankle or foot that allow humans to walk on two legs". Evidence to date shows that of the 110,000 gene enhancer sequences identified in the human genome, HACNS1 has undergone the most change during the evolution of humans following the split with the ancestors of chimpanzees. The substitutions in HAR2 may have resulted in loss of binding sites for a repressor, possibly due to biased gene conversion.".
- Q1968369 thumbnail Details_of_HAR1–HAR5_journal.pgen.0020168.t001.png?width=300.
- Q1968369 wikiPageExternalLink index.html.
- Q1968369 wikiPageExternalLink haussler20060816.html.
- Q1968369 wikiPageExternalLink nature05113-s1.doc.
- Q1968369 wikiPageExternalLink article.cfm?chanID=sa003&articleID=00023D61-9116-14E3-911683414B7F0000.
- Q1968369 wikiPageExternalLink article.cfm?id=what-makes-us-human.
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- Q1968369 wikiPageWikiLink Q4926419.
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- Q1968369 comment "Human accelerated regions (HARs), first described in August 2006, are a set of 49 segments of the human genome that are conserved throughout vertebrate evolution but are strikingly different in humans. They are named according to their degree of difference between humans and chimpanzees (HAR1 showing the largest degree of human-chimpanzee differences). Found by scanning through genomic databases of multiple species, some of these highly mutated areas may contribute to human-specific traits.".
- Q1968369 label "Human accelerated regions".
- Q1968369 depiction Details_of_HAR1–HAR5_journal.pgen.0020168.t001.png.