Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q19597510> ?p ?o }
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- Q19597510 subject Q20010658.
- Q19597510 subject Q7310239.
- Q19597510 subject Q7334131.
- Q19597510 subject Q8546974.
- Q19597510 subject Q8672733.
- Q19597510 subject Q8873943.
- Q19597510 abstract "HIOC is a small-molecule agent which acts as a selective TrkB receptor agonist (active at at least 100 nM; prominent activation at 500 nM). It was derived from N-acetylserotonin (NAS). Relative to NAS, HIOC possesses greater potency and a longer half-life (~30 min or less for NAS in rats, while HIOC is still detectable up to 24 hours after administration to mice; ~4 hour half-life for HIOC in mouse brain tissues). It is described as producing long-lasting activation of the TrkB receptor and downstream signaling kinases associated with the receptor. HIOC is systemically-active and is able to penetrate the blood-brain-barrier. In animal studies, HIOC was found to robustly protect against glutamate-induced excitotoxicity, an action which was TrkB-dependent.A chemical synthesis of HIOC has been published recently.".
- Q19597510 atcPrefix "None".
- Q19597510 iupacName "N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-oxo-3-piperidinecarboxamide".
- Q19597510 pubchem "5012758".
- Q19597510 thumbnail HIOC.svg?width=300.
- Q19597510 wikiPageWikiLink Q14897782.
- Q19597510 wikiPageWikiLink Q181136.
- Q19597510 wikiPageWikiLink Q19596931.
- Q19597510 wikiPageWikiLink Q1988322.
- Q19597510 wikiPageWikiLink Q20010658.
- Q19597510 wikiPageWikiLink Q213907.
- Q19597510 wikiPageWikiLink Q221694.
- Q19597510 wikiPageWikiLink Q273499.
- Q19597510 wikiPageWikiLink Q389934.
- Q19597510 wikiPageWikiLink Q47270.
- Q19597510 wikiPageWikiLink Q4847704.
- Q19597510 wikiPageWikiLink Q58321.
- Q19597510 wikiPageWikiLink Q7310239.
- Q19597510 wikiPageWikiLink Q7334131.
- Q19597510 wikiPageWikiLink Q7663812.
- Q19597510 wikiPageWikiLink Q8386.
- Q19597510 wikiPageWikiLink Q8546974.
- Q19597510 wikiPageWikiLink Q8672733.
- Q19597510 wikiPageWikiLink Q8873943.
- Q19597510 wikiPageWikiLink Q901117.
- Q19597510 atcPrefix "None".
- Q19597510 iupacName "N-[2-ethyl]-2-oxo-3-piperidinecarboxamide".
- Q19597510 pubchem "5012758".
- Q19597510 type ChemicalSubstance.
- Q19597510 type Drug.
- Q19597510 type ChemicalObject.
- Q19597510 type Thing.
- Q19597510 type Q8386.
- Q19597510 comment "HIOC is a small-molecule agent which acts as a selective TrkB receptor agonist (active at at least 100 nM; prominent activation at 500 nM). It was derived from N-acetylserotonin (NAS). Relative to NAS, HIOC possesses greater potency and a longer half-life (~30 min or less for NAS in rats, while HIOC is still detectable up to 24 hours after administration to mice; ~4 hour half-life for HIOC in mouse brain tissues).".
- Q19597510 label "HIOC".
- Q19597510 depiction HIOC.svg.