Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q18394897> ?p ?o }
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- Q18394897 subject Q8297683.
- Q18394897 subject Q8375173.
- Q18394897 subject Q8645495.
- Q18394897 subject Q8878420.
- Q18394897 subject Q8919936.
- Q18394897 subject Q9134654.
- Q18394897 abstract "U-47700 is an opioid analgesic drug developed by a team at Upjohn in the 1970s. U-47700 was derived from an earlier opioid AH-7921. U-47700 is selective for the µ-opioid receptor, having around 7.5 x the potency of morphine in animal models.U-47700 is the result of a great deal of work elucidating the quantitative structure–activity relationship of the scaffold. The team looked for the key moieties which gave the greatest activity. Upjohn posted over a dozen patents on related compounds, each optimizing one moiety until they discovered that U-47700 was the most active.U-47700 became the lead compound of selective kappa-opioid receptor ligands such as U-50488 (containing a single methylene spacer difference) and U-69,593, which share very similar structures. Its structure led to other chemists experimenting with it to see if rigid analogues would retain activity. Although not used medically, the selective kappa ligands are used in research.".
- Q18394897 casNumber "121348-98-9".
- Q18394897 iupacName "trans-3,4-dichloro-N-(2-(dimethylamino)cyclohexyl)-N-methylbenzamide".
- Q18394897 pubchem "13544015".
- Q18394897 thumbnail U-47700_structure.svg?width=300.
- Q18394897 wikiPageWikiLink Q1200715.
- Q18394897 wikiPageWikiLink Q14911924.
- Q18394897 wikiPageWikiLink Q16266700.
- Q18394897 wikiPageWikiLink Q173235.
- Q18394897 wikiPageWikiLink Q23005640.
- Q18394897 wikiPageWikiLink Q407541.
- Q18394897 wikiPageWikiLink Q427523.
- Q18394897 wikiPageWikiLink Q4651730.
- Q18394897 wikiPageWikiLink Q766383.
- Q18394897 wikiPageWikiLink Q7862881.
- Q18394897 wikiPageWikiLink Q7862883.
- Q18394897 wikiPageWikiLink Q81225.
- Q18394897 wikiPageWikiLink Q8297683.
- Q18394897 wikiPageWikiLink Q8375173.
- Q18394897 wikiPageWikiLink Q8645495.
- Q18394897 wikiPageWikiLink Q8878420.
- Q18394897 wikiPageWikiLink Q8919936.
- Q18394897 wikiPageWikiLink Q9134654.
- Q18394897 casNumber "121348".
- Q18394897 iupacName "trans-3,4-dichloro-N--N-methylbenzamide".
- Q18394897 pubchem "13544015".
- Q18394897 type ChemicalSubstance.
- Q18394897 type Drug.
- Q18394897 type ChemicalObject.
- Q18394897 type Thing.
- Q18394897 type Q8386.
- Q18394897 comment "U-47700 is an opioid analgesic drug developed by a team at Upjohn in the 1970s. U-47700 was derived from an earlier opioid AH-7921. U-47700 is selective for the µ-opioid receptor, having around 7.5 x the potency of morphine in animal models.U-47700 is the result of a great deal of work elucidating the quantitative structure–activity relationship of the scaffold. The team looked for the key moieties which gave the greatest activity.".
- Q18394897 label "U-47700".
- Q18394897 depiction U-47700_structure.svg.