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- Q18205331 subject Q6584222.
- Q18205331 abstract "Aspergillomarasmine A is an polyamino acid naturally produced by the mold Aspergillus versicolor. The substance has been reported to inhibit two antibiotic resistance carbapenemase proteins in bacteria, New Delhi metallo-beta-lactamase 1 (NDM-1) and Verona integron-encoded metallo-beta-lactamase (VIM-2), and make those antibiotic-resistant bacteria susceptible to antibiotics. Aspergillomarasmine A is toxic to leaves of barley and other plants, being termed as "Toxin C" when produced by Pyrenophora teres.The molecule is a tetracarboxylic acid with four -COOH groups. One section of the molecule is the amino acid aspartic acid. This has two alanine molecules attached. Aspergillomarasmine B differs in that the last alanine is replaced by glycine.The crystalline substance was first isolated in 1956, but its name was given until 1965.In addition to Aspergillus versicolor, aspergillomarasmine A is also produced by the ascomycete Pyrenophora teres where it acts as a toxin in the barley net-spot blotch disease. In P. teres, a biosynthetic precursor of aspergillomarasmine A, L,L-N-(2-amino-2-carboxyethyl)-aspartic acid has also been isolated and found to contribute to the phytotoxic properties of this microbe. This precursor, aspergillomarasmine A itself, and a lactam form (anhydroaspergillomarasmine A) are together termed the marasmines.Other producers of aspergillomarasmine A include Aspergillus flavus, Aspergillus oryzae, Colletotrichum gloeosporioides, and Fusarium oxysporum.In mice the LD50 toxic dose of aspergillomarasmine A is 159.8 mg/kg.".
- Q18205331 iupacName "(R-(R*,R*))-N-(2-((2-Amino-2-carboxyethyl)amino)-2-carboxyethyl)-L-aspartic acid".
- Q18205331 thumbnail Aspergillomarasmine_A.svg?width=300.
- Q18205331 wikiPageWikiLink Q103135.
- Q18205331 wikiPageWikiLink Q10420082.
- Q18205331 wikiPageWikiLink Q11577.
- Q18205331 wikiPageWikiLink Q131911.
- Q18205331 wikiPageWikiLink Q134856.
- Q18205331 wikiPageWikiLink Q137096.
- Q18205331 wikiPageWikiLink Q139958.
- Q18205331 wikiPageWikiLink Q146505.
- Q18205331 wikiPageWikiLink Q178450.
- Q18205331 wikiPageWikiLink Q18023073.
- Q18205331 wikiPageWikiLink Q191010.
- Q18205331 wikiPageWikiLink Q192036.
- Q18205331 wikiPageWikiLink Q218642.
- Q18205331 wikiPageWikiLink Q251124.
- Q18205331 wikiPageWikiLink Q311379.
- Q18205331 wikiPageWikiLink Q319827.
- Q18205331 wikiPageWikiLink Q3233795.
- Q18205331 wikiPageWikiLink Q3772404.
- Q18205331 wikiPageWikiLink Q380775.
- Q18205331 wikiPageWikiLink Q412033.
- Q18205331 wikiPageWikiLink Q421098.
- Q18205331 wikiPageWikiLink Q425402.
- Q18205331 wikiPageWikiLink Q620730.
- Q18205331 wikiPageWikiLink Q628025.
- Q18205331 wikiPageWikiLink Q6584222.
- Q18205331 wikiPageWikiLink Q711849.
- Q18205331 wikiPageWikiLink Q7263460.
- Q18205331 wikiPageWikiLink Q869588.
- Q18205331 wikiPageWikiLink Q898254.
- Q18205331 iupacname "-N--L-aspartic acid".
- Q18205331 type ChemicalCompound.
- Q18205331 type ChemicalSubstance.
- Q18205331 type ChemicalObject.
- Q18205331 type Thing.
- Q18205331 type Q11173.
- Q18205331 comment "Aspergillomarasmine A is an polyamino acid naturally produced by the mold Aspergillus versicolor. The substance has been reported to inhibit two antibiotic resistance carbapenemase proteins in bacteria, New Delhi metallo-beta-lactamase 1 (NDM-1) and Verona integron-encoded metallo-beta-lactamase (VIM-2), and make those antibiotic-resistant bacteria susceptible to antibiotics.".
- Q18205331 label "Aspergillomarasmine A".
- Q18205331 depiction Aspergillomarasmine_A.svg.