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- Q18043017 subject Q6984105.
- Q18043017 subject Q7145822.
- Q18043017 subject Q8395801.
- Q18043017 subject Q8420217.
- Q18043017 abstract "Activation-induced cytidine deaminase, also known as AICDA and AID, is a 24 kDa enzyme which in humans is encoded by the AICDA gene. It creates mutations in DNA by deamination of cytosine base, which turns it into uracil (which is recognized as a thymine). In other words, it changes a C:G base pair into a U:G mismatch. The cell's DNA replication machinery recognizes the U as a T, and hence C:G is converted to a T:A base pair. During germinal center development of B lymphocytes, AID also generates other types of mutations, such as C:G to A:T. The mechanism by which these other mutations are created is not well-understood.In B cells in the lymph nodes, AID causes mutations that produce antibody diversity, but that same mutation process leads to B cell lymphoma.".
- Q18043017 entrezgene "57379".
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- Q18043017 wikiPageWikiLink Q6984105.
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- Q18043017 wikiPageWikiLink Q8420217.
- Q18043017 type Biomolecule.
- Q18043017 type Protein.
- Q18043017 type Thing.
- Q18043017 type Q206229.
- Q18043017 type Q8054.
- Q18043017 comment "Activation-induced cytidine deaminase, also known as AICDA and AID, is a 24 kDa enzyme which in humans is encoded by the AICDA gene. It creates mutations in DNA by deamination of cytosine base, which turns it into uracil (which is recognized as a thymine). In other words, it changes a C:G base pair into a U:G mismatch. The cell's DNA replication machinery recognizes the U as a T, and hence C:G is converted to a T:A base pair.".
- Q18043017 label "Activation-induced cytidine deaminase".