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- Q18041145 abstract "UDP-glucuronosyltransferase 1-4 is an enzyme that in humans is encoded by the UGT1A4 gene.This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5′ exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although it is more active on amines, steroids, and sapogenins. It is the main enzyme responsible for glucuronidation of the anticonvulsant lamotrigine.".
- Q18041145 entrezgene "54657".
- Q18041145 wikiPageWikiLink Q104219.
- Q18041145 wikiPageWikiLink Q167198.
- Q18041145 wikiPageWikiLink Q177911.
- Q18041145 wikiPageWikiLink Q1995607.
- Q18041145 wikiPageWikiLink Q284398.
- Q18041145 wikiPageWikiLink Q310425.
- Q18041145 wikiPageWikiLink Q373027.
- Q18041145 wikiPageWikiLink Q407595.
- Q18041145 wikiPageWikiLink Q410346.
- Q18041145 wikiPageWikiLink Q419543.
- Q18041145 wikiPageWikiLink Q576618.
- Q18041145 wikiPageWikiLink Q7187.
- Q18041145 wikiPageWikiLink Q7421001.
- Q18041145 wikiPageWikiLink Q8047.
- Q18041145 wikiPageWikiLink Q898401.
- Q18041145 wikiPageWikiLink Q901125.
- Q18041145 type Biomolecule.
- Q18041145 type Protein.
- Q18041145 type Thing.
- Q18041145 type Q206229.
- Q18041145 type Q8054.
- Q18041145 comment "UDP-glucuronosyltransferase 1-4 is an enzyme that in humans is encoded by the UGT1A4 gene.This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons.".
- Q18041145 label "UGT1A4".