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- Q18035399 abstract "Transmembrane glycoprotein NMB is a protein that in humans is encoded by the GPNMB gene. The mouse and rat orthologues of GPNMB are known as DC-HIL and Osteoactivin (OA), respectively. Two transcript variants encoding 560 and 572 amino acid isoforms have been characterized for this gene in humans. GPNMB is a type I transmembrane glycoprotein which shows homology to the pmel17 precursor, a melanocyte-specific protein.GPNMB has been reported to be expressed in various cell types, including: melanocytes, osteoclasts, osteoblasts, dendritic cells, and it is overexpressed in various cancer types. In melanocytic cells and osteoclasts the GPNMB gene is transcritionally regulated by Microphthalmia-associated transcription factor. In osteoblast progenitor cells, Osteoactivin works as a positive regulator of osteoblast differentiation during later stages of matrix maturation and mineralization that is mediated at least in part by BMP-2 in a SMAD1 dependent manner to promote osteoblast differentiation. In addition, using a rat fracture model, Osteoactivin (OA) enhances the repairing process in bone fracture, demonstrated by its high expression during chondrogenesis (soft callus) and osteogenesis (hard callus) compared to the intact femurs that is why Osteoactivin (OA) could be a novel therapeutic agent used to treat generalized osteoporosis or localized osteopenia during fracture repair by stimulating bone growth and regeneration. Similarly, Osteoactivin expression increases during osteoclast differentiation and it is functionally implicated in this process, possibly by promoting the fusion of osteoclast progenitor cells.".
- Q18035399 entrezgene "10457".
- Q18035399 wikiPageExternalLink pmidlookup?view=long&pmid=12176896.
- Q18035399 wikiPageExternalLink pmidlookup?view=long&pmid=9847074.
- Q18035399 wikiPageExternalLink abstract.php?id=1468.
- Q18035399 wikiPageWikiLink Q1121544.
- Q18035399 wikiPageWikiLink Q1216998.
- Q18035399 wikiPageWikiLink Q128581.
- Q18035399 wikiPageWikiLink Q1365309.
- Q18035399 wikiPageWikiLink Q14903784.
- Q18035399 wikiPageWikiLink Q14906495.
- Q18035399 wikiPageWikiLink Q160357.
- Q18035399 wikiPageWikiLink Q165328.
- Q18035399 wikiPageWikiLink Q18031504.
- Q18035399 wikiPageWikiLink Q180614.
- Q18035399 wikiPageWikiLink Q181876.
- Q18035399 wikiPageWikiLink Q187126.
- Q18035399 wikiPageWikiLink Q189092.
- Q18035399 wikiPageWikiLink Q247101.
- Q18035399 wikiPageWikiLink Q3771944.
- Q18035399 wikiPageWikiLink Q41301.
- Q18035399 wikiPageWikiLink Q424204.
- Q18035399 wikiPageWikiLink Q4774572.
- Q18035399 wikiPageWikiLink Q5104524.
- Q18035399 wikiPageWikiLink Q558313.
- Q18035399 wikiPageWikiLink Q6901739.
- Q18035399 wikiPageWikiLink Q7187.
- Q18035399 wikiPageWikiLink Q7843332.
- Q18035399 wikiPageWikiLink Q8054.
- Q18035399 wikiPageWikiLink Q899285.
- Q18035399 type Biomolecule.
- Q18035399 type Protein.
- Q18035399 type Thing.
- Q18035399 type Q206229.
- Q18035399 type Q8054.
- Q18035399 comment "Transmembrane glycoprotein NMB is a protein that in humans is encoded by the GPNMB gene. The mouse and rat orthologues of GPNMB are known as DC-HIL and Osteoactivin (OA), respectively. Two transcript variants encoding 560 and 572 amino acid isoforms have been characterized for this gene in humans.".
- Q18035399 label "GPNMB".