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- Q18033167 abstract "Src kinase-associated phosphoprotein 1 is an adapter protein that in humans is encoded by the SKAP1 gene.This gene encodes a T cell adapter protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adapter protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.The demonstration that SKAP1 regulates LFA-1 adhesion was made by retroviral infection and by the SKAP1 deficient mouse. Additional work has implicated SKAP1 in binding to the exchange factor RasGRP1 and in regulating ERK activation in T-cells.".
- Q18033167 entrezgene "8631".
- Q18033167 wikiPageWikiLink Q103537.
- Q18033167 wikiPageWikiLink Q14906003.
- Q18033167 wikiPageWikiLink Q18024891.
- Q18033167 wikiPageWikiLink Q18024903.
- Q18033167 wikiPageWikiLink Q18035049.
- Q18033167 wikiPageWikiLink Q193529.
- Q18033167 wikiPageWikiLink Q284398.
- Q18033167 wikiPageWikiLink Q310425.
- Q18033167 wikiPageWikiLink Q33101.
- Q18033167 wikiPageWikiLink Q36506.
- Q18033167 wikiPageWikiLink Q4042438.
- Q18033167 wikiPageWikiLink Q409325.
- Q18033167 wikiPageWikiLink Q409715.
- Q18033167 wikiPageWikiLink Q5964993.
- Q18033167 wikiPageWikiLink Q7187.
- Q18033167 wikiPageWikiLink Q896177.
- Q18033167 wikiPageWikiLink Q901088.
- Q18033167 type Biomolecule.
- Q18033167 type Protein.
- Q18033167 type Thing.
- Q18033167 type Q206229.
- Q18033167 type Q8054.
- Q18033167 comment "Src kinase-associated phosphoprotein 1 is an adapter protein that in humans is encoded by the SKAP1 gene.This gene encodes a T cell adapter protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain.".
- Q18033167 label "SKAP1".