Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q18032422> ?p ?o }
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- Q18032422 abstract "ZIC3 is a member of the Zinc finger of the cerebellum (ZIC) protein family.ZIC3 is classified as a ZIC protein due to conservation of the five C2H2 zinc fingers, which enables the protein to interact with DNA and proteins. Correct function of this protein family in critical for early development, and as such mutations of the genes encoding these proteins is known to result in various congenital defects. For example, mutation of ZIC3 is associated with heterotaxy, that is thought to occur due to the role of ZIC3 in initial left-right symmetry formation, which involves the maintaining redistributed Nodal after the asymmetry of the embryo is initially broken. Mutation of ZIC3 is also associated with various heart defects, such as heart looping, however these are thought to represent a mild form of heterotaxy. Mouse based studies have linked defective ZIC3 with neural tube defects (spina bifida) and skeletal defects.ZIC3 is also of particular interest as it has been shown to be required for maintenance of embryonic stem cell pluripotency.".
- Q18032422 entrezgene "7547".
- Q18032422 wikiPageWikiLink Q18032421.
- Q18032422 wikiPageWikiLink Q203115.
- Q18032422 wikiPageWikiLink Q8054.
- Q18032422 wikiPageWikiLink Q844717.
- Q18032422 wikiPageWikiLink Q862600.
- Q18032422 type Biomolecule.
- Q18032422 type Protein.
- Q18032422 type Thing.
- Q18032422 type Q206229.
- Q18032422 type Q8054.
- Q18032422 comment "ZIC3 is a member of the Zinc finger of the cerebellum (ZIC) protein family.ZIC3 is classified as a ZIC protein due to conservation of the five C2H2 zinc fingers, which enables the protein to interact with DNA and proteins. Correct function of this protein family in critical for early development, and as such mutations of the genes encoding these proteins is known to result in various congenital defects.".
- Q18032422 label "ZIC3".