Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q17917469> ?p ?o }
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- Q17917469 subject Q7348603.
- Q17917469 abstract "ERCC4 is a protein designated as DNA repair endonuclease XPF that in humans is encoded by the ERCC4 gene. Together with ERCC1, ERCC4 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination.The nuclease enzyme ERCC1-XPF cuts specific structures of DNA. Many aspects of these two gene products are described together here because they are partners during DNA repair. The ERCC1-XPF nuclease is an essential activity in the pathway of DNA nucleotide excision repair (NER). The ERCC1-XPF nuclease also functions in pathways to repair double-strand breaks in DNA, and in the repair of “crosslink” damage that harmfully links the two DNA strands.Cells with disabling mutations in ERCC4 are more sensitive than normal to particular DNA damaging agents, including ultraviolet radiation and to chemicals that cause crosslinking between DNA strands. Genetically engineered mice with disabling mutations in ERCC4 also have defects in DNA repair, accompanied by metabolic stress-induced changes in physiology that result in premature aging. Complete deletion of ERCC4 is incompatible with viability of mice, and no human individuals have been found with complete (homozygous) deletion of ERCC4. Rare individuals in the human population harbor inherited mutations that impair the function of ERCC4. When the normal genes are absent, these mutations can lead to human syndromes, including xeroderma pigmentosum, Cockayne syndrome and Fanconi anemia.ERCC1 and ERCC4 are the human gene names and Ercc1 and Ercc4 are the analogous mammalian gene names. Similar genes with similar functions are found in all eukaryotic organisms.".
- Q17917469 entrezgene "2072".
- Q17917469 thumbnail Fig_1_XPF_Wikigene.png?width=300.
- Q17917469 wikiPageExternalLink br.fcgi?book=gene&part=xp.
- Q17917469 wikiPageWikiLink Q11083.
- Q17917469 wikiPageWikiLink Q11391.
- Q17917469 wikiPageWikiLink Q1141325.
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- Q17917469 wikiPageWikiLink Q1364740.
- Q17917469 wikiPageWikiLink Q1725675.
- Q17917469 wikiPageWikiLink Q17917256.
- Q17917469 wikiPageWikiLink Q1823851.
- Q17917469 wikiPageWikiLink Q210538.
- Q17917469 wikiPageWikiLink Q224180.
- Q17917469 wikiPageWikiLink Q2389557.
- Q17917469 wikiPageWikiLink Q26939.
- Q17917469 wikiPageWikiLink Q2714458.
- Q17917469 wikiPageWikiLink Q285697.
- Q17917469 wikiPageWikiLink Q40260.
- Q17917469 wikiPageWikiLink Q4115375.
- Q17917469 wikiPageWikiLink Q422529.
- Q17917469 wikiPageWikiLink Q48196.
- Q17917469 wikiPageWikiLink Q509615.
- Q17917469 wikiPageWikiLink Q612693.
- Q17917469 wikiPageWikiLink Q7187.
- Q17917469 wikiPageWikiLink Q7348603.
- Q17917469 wikiPageWikiLink Q8054.
- Q17917469 wikiPageWikiLink Q845779.
- Q17917469 wikiPageWikiLink Q914389.
- Q17917469 type Biomolecule.
- Q17917469 type Protein.
- Q17917469 type Thing.
- Q17917469 type Q206229.
- Q17917469 type Q8054.
- Q17917469 comment "ERCC4 is a protein designated as DNA repair endonuclease XPF that in humans is encoded by the ERCC4 gene. Together with ERCC1, ERCC4 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination.The nuclease enzyme ERCC1-XPF cuts specific structures of DNA. Many aspects of these two gene products are described together here because they are partners during DNA repair.".
- Q17917469 label "ERCC4".
- Q17917469 depiction Fig_1_XPF_Wikigene.png.