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- Q17153149 subject Q7145140.
- Q17153149 abstract "Acyldepsipeptide or cyclic acyldepsipeptide (ADEP) is a class of potential antibiotics first isolated from bacteria. Natural ADEPs were originally found as products of aerobic fermentation in Streptomyces hawaiiensis, A54556A and B, and in the culture broth of Streptomyces species, enopeptin A and B. ADEPs are of great interest in drug development due to their antibiotic properties and thus are being modified in attempt to achieve greater antimicrobial activity.The potential role of ADEPs in combating antibiotic drug resistance is postulated due to their novel mode of action that other antibiotics are not known to use, activation of casein lytic protease (ClpP) which is an important bacterial protease. Most antibiotics work through inhibitory processes to establish cell death, while ADEPs actually work through activation of the protease complex to cause uncontrolled protease degradation, inhibition of cell division, and subsequent cell death. They largely affect Gram-positive bacteria and could be of great use to target antibiotic resistant microbes such as methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumonia (PRSP), Mycobacterium tuberculosis, and others. Despite the potential use of ADEP, possible resistance has been examined in certain species.".
- Q17153149 thumbnail Enopeptin_A.svg?width=300.
- Q17153149 wikiPageExternalLink explore.do?structureId=3kti.
- Q17153149 wikiPageWikiLink Q1057.
- Q17153149 wikiPageWikiLink Q12119506.
- Q17153149 wikiPageWikiLink Q12187.
- Q17153149 wikiPageWikiLink Q130971.
- Q17153149 wikiPageWikiLink Q178859.
- Q17153149 wikiPageWikiLink Q188121.
- Q17153149 wikiPageWikiLink Q188909.
- Q17153149 wikiPageWikiLink Q189115.
- Q17153149 wikiPageWikiLink Q212410.
- Q17153149 wikiPageWikiLink Q219567.
- Q17153149 wikiPageWikiLink Q22665885.
- Q17153149 wikiPageWikiLink Q284398.
- Q17153149 wikiPageWikiLink Q2902610.
- Q17153149 wikiPageWikiLink Q380775.
- Q17153149 wikiPageWikiLink Q413248.
- Q17153149 wikiPageWikiLink Q41760.
- Q17153149 wikiPageWikiLink Q422496.
- Q17153149 wikiPageWikiLink Q4649768.
- Q17153149 wikiPageWikiLink Q4654881.
- Q17153149 wikiPageWikiLink Q5012788.
- Q17153149 wikiPageWikiLink Q5448273.
- Q17153149 wikiPageWikiLink Q595158.
- Q17153149 wikiPageWikiLink Q647203.
- Q17153149 wikiPageWikiLink Q7145140.
- Q17153149 wikiPageWikiLink Q8066.
- Q17153149 wikiPageWikiLink Q845326.
- Q17153149 wikiPageWikiLink Q857288.
- Q17153149 comment "Acyldepsipeptide or cyclic acyldepsipeptide (ADEP) is a class of potential antibiotics first isolated from bacteria. Natural ADEPs were originally found as products of aerobic fermentation in Streptomyces hawaiiensis, A54556A and B, and in the culture broth of Streptomyces species, enopeptin A and B.".
- Q17153149 label "Acyldepsipeptide antibiotics".
- Q17153149 depiction Enopeptin_A.svg.