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- Q17125871 subject Q7204727.
- Q17125871 subject Q8266666.
- Q17125871 abstract "PRC2 (Polycomb Repressive Complex 2) is one of the two classes of polycomb-group proteins or (PcG). The other component of this group of proteins is PRC1.This complex has histone methyltransferase activity and primarily trimethylates histone H3 on lysine 27 (i.e. H3K27me3), a mark of transcriptionally silent chromatin. PRC2 is required for initial targeting of genomic region (PRC Response Elements or PRE) to be silenced, while PRC1 is required for stabilizing this silencing and underlies cellular memory of silenced region after cellular differentiation. PRC1 also mono-ubiquitinates histone H2A on lysine 119 (H2AK119Ub1). These proteins are required for long term epigenetic silencing of chromatin and have an important role in stem cell differentiation and early embryonic development. PRC2 are present in all multicellular organisms.The mouse PRC2 has four subunits: Suz12 (zinc finger), Eed, Ezh1 or Ezh2 (SET domain with histone methyltransferase activity) and RbAp48 (histone binding domain)PRC2 has a role in X chromosome inactivation, in maintenance of stem cell fate, and in imprinting. Aberrant expression of PRC2 has been observed in cancer.".
- Q17125871 wikiPageWikiLink Q12078.
- Q17125871 wikiPageWikiLink Q1431332.
- Q17125871 wikiPageWikiLink Q178430.
- Q17125871 wikiPageWikiLink Q18037228.
- Q17125871 wikiPageWikiLink Q180951.
- Q17125871 wikiPageWikiLink Q189148.
- Q17125871 wikiPageWikiLink Q204785.
- Q17125871 wikiPageWikiLink Q210861.
- Q17125871 wikiPageWikiLink Q26939.
- Q17125871 wikiPageWikiLink Q33196.
- Q17125871 wikiPageWikiLink Q36293.
- Q17125871 wikiPageWikiLink Q36458.
- Q17125871 wikiPageWikiLink Q4082046.
- Q17125871 wikiPageWikiLink Q415875.
- Q17125871 wikiPageWikiLink Q48196.
- Q17125871 wikiPageWikiLink Q4914012.
- Q17125871 wikiPageWikiLink Q61333.
- Q17125871 wikiPageWikiLink Q7204727.
- Q17125871 wikiPageWikiLink Q7389899.
- Q17125871 wikiPageWikiLink Q8054.
- Q17125871 wikiPageWikiLink Q8266666.
- Q17125871 wikiPageWikiLink Q911591.
- Q17125871 comment "PRC2 (Polycomb Repressive Complex 2) is one of the two classes of polycomb-group proteins or (PcG). The other component of this group of proteins is PRC1.This complex has histone methyltransferase activity and primarily trimethylates histone H3 on lysine 27 (i.e. H3K27me3), a mark of transcriptionally silent chromatin.".
- Q17125871 label "PRC2".