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- Q15640018 subject Q11721471.
- Q15640018 abstract "Mannomustine (INN), also known as mannitol nitrogen mustard, tradename Degranol is an old alkylating antineoplastic agent from the group of nitrogen mustards. It was first synthesized and characterized in 1957 by Vargha et al.The mechanism of antineoplastic activity of mannomustine, like for all other alkylating agents, lies in its ability to alkylate DNA guanine nucleobases and, thus, to prevent uncoupling of DNA strands, which is a required step for any cell to divide.Mannomustine was, at the time of its creation as a drug, claimed to be considerably less toxic than mechlorethamine. For example, the LD50 in rats, for intravenous mannomustine administration route, is claimed to be about 56 mg/kg.".
- Q15640018 atcPrefix "L01".
- Q15640018 casNumber "576-68-1".
- Q15640018 casSupplemental "551-74-6".
- Q15640018 iupacName "(2-chloroethyl)({6-[(2-chloroethyl)amino]-2,3,4,5-tetrahydroxyhexyl})amine".
- Q15640018 pubchem "3033867".
- Q15640018 thumbnail Mannomustine_chemical_structure.gif?width=300.
- Q15640018 wikiPageWikiLink Q11721471.
- Q15640018 wikiPageWikiLink Q169313.
- Q15640018 wikiPageWikiLink Q335268.
- Q15640018 wikiPageWikiLink Q414004.
- Q15640018 wikiPageWikiLink Q418011.
- Q15640018 wikiPageWikiLink Q422960.
- Q15640018 wikiPageWikiLink Q432083.
- Q15640018 wikiPageWikiLink Q619908.
- Q15640018 wikiPageWikiLink Q7430.
- Q15640018 wikiPageWikiLink Q824258.
- Q15640018 wikiPageWikiLink Q9368.
- Q15640018 wikiPageWikiLink Q9377.
- Q15640018 wikiPageWikiLink Q974135.
- Q15640018 atcPrefix "L01".
- Q15640018 casNumber "576".
- Q15640018 casSupplemental "551".
- Q15640018 iupacName "amine".
- Q15640018 pubchem "3033867".
- Q15640018 type ChemicalSubstance.
- Q15640018 type Drug.
- Q15640018 type ChemicalObject.
- Q15640018 type Thing.
- Q15640018 type Q8386.
- Q15640018 comment "Mannomustine (INN), also known as mannitol nitrogen mustard, tradename Degranol is an old alkylating antineoplastic agent from the group of nitrogen mustards.".
- Q15640018 label "Mannomustine".
- Q15640018 depiction Mannomustine_chemical_structure.gif.