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- Q15426668 subject Q8565752.
- Q15426668 subject Q8791920.
- Q15426668 subject Q8824860.
- Q15426668 subject Q9694863.
- Q15426668 abstract "Saridegib also known as IPI-926 is an experimental drug candidate undergoing clinical trials for the treatment of various types of cancer, including hard to treat hematologic malignancies such as myelofibrosis and ligand-dependant tumors such as chondrosarcoma. IPI-926 exhibits its pharmacological effect by inhibition of the G protein-coupled receptor smoothened, a component of the hedgehog signaling pathway. Chemically, it is a semi-synthetic derivative of the alkaloid cyclopamine. The process begins with cyclopamine extracted from harvested Veratrum californicum which is taken through a series of alterations resulting in an analogue of the natural product cyclopamine, making IPI-926 the only compound in development/testing that is not fully synthetic.".
- Q15426668 iupacName "N-((2S,3R,3aS,3′R,4a′R,6S,6a′R,6b′S,7aR,12a&prmie;S,12b′S)-3,6,11′,12b′-tetramethyl-2′,3a,3′,4,4′,4a′,5,5&prmie;,6,6′,6a′,6b′,7,7a,7′,8′,10′,12′,12a′,12b′-icosahydro-1′H,3H-spiro[furo[3,2-b]pyridine-2,9'-naphtho[2,1-a]azulen]-3'-yl)methanesulfonamide".
- Q15426668 thumbnail Saridegib.svg?width=300.
- Q15426668 wikiPageWikiLink Q18031607.
- Q15426668 wikiPageWikiLink Q204711.
- Q15426668 wikiPageWikiLink Q2712513.
- Q15426668 wikiPageWikiLink Q3271319.
- Q15426668 wikiPageWikiLink Q38173.
- Q15426668 wikiPageWikiLink Q4926095.
- Q15426668 wikiPageWikiLink Q70702.
- Q15426668 wikiPageWikiLink Q8565752.
- Q15426668 wikiPageWikiLink Q8791920.
- Q15426668 wikiPageWikiLink Q8824860.
- Q15426668 wikiPageWikiLink Q898317.
- Q15426668 wikiPageWikiLink Q903852.
- Q15426668 wikiPageWikiLink Q9694863.
- Q15426668 iupacname "N-methanesulfonamide".
- Q15426668 type ChemicalCompound.
- Q15426668 type ChemicalSubstance.
- Q15426668 type ChemicalObject.
- Q15426668 type Thing.
- Q15426668 type Q11173.
- Q15426668 comment "Saridegib also known as IPI-926 is an experimental drug candidate undergoing clinical trials for the treatment of various types of cancer, including hard to treat hematologic malignancies such as myelofibrosis and ligand-dependant tumors such as chondrosarcoma. IPI-926 exhibits its pharmacological effect by inhibition of the G protein-coupled receptor smoothened, a component of the hedgehog signaling pathway. Chemically, it is a semi-synthetic derivative of the alkaloid cyclopamine.".
- Q15426668 label "Saridegib".
- Q15426668 depiction Saridegib.svg.