Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q14905324> ?p ?o }
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- Q14905324 subject Q7204727.
- Q14905324 abstract "Integrin alpha M (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM is also known as CR3A, and cluster of differentiation molecule 11B (CD11B). The second chain of αMβ2 is the common integrin β2 subunit known as CD18, and integrin αMβ2 thus belongs to the β2 subfamily (or leukocyte) integrins.αMβ2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation. It is involved in the complement system due to its capacity to bind inactivated complement component 3b (iC3b). The ITGAM (alpha) subunit of integrin αMβ2 is directly involved in causing the adhesion and spreading of cells but cannot mediate cellular migration without the presence of the β2 (CD18) subunit.In genomewide association studies, single nucleotide polymorphisms in ITGAM had the strongest association with systemic lupus erythematosus, with an odds ratio of 1.65 for the T allele of rs9888739 and lupus.In histopathology, immunohistochemistry with antibodies against CD11B is frequently used to identify macrophages and microglia.".
- Q14905324 entrezgene "3684".
- Q14905324 wikiPageExternalLink report.cgi?report=orth_overview&gene_id=3684.
- Q14905324 wikiPageExternalLink index.shtml.
- Q14905324 wikiPageExternalLink humancdchart.htm.
- Q14905324 wikiPageExternalLink mousecdchart.htm.
- Q14905324 wikiPageWikiLink Q1070952.
- Q14905324 wikiPageWikiLink Q107244.
- Q14905324 wikiPageWikiLink Q1103544.
- Q14905324 wikiPageWikiLink Q1485.
- Q14905324 wikiPageWikiLink Q14874317.
- Q14905324 wikiPageWikiLink Q14912067.
- Q14905324 wikiPageWikiLink Q1622829.
- Q14905324 wikiPageWikiLink Q184204.
- Q14905324 wikiPageWikiLink Q184726.
- Q14905324 wikiPageWikiLink Q187640.
- Q14905324 wikiPageWikiLink Q223143.
- Q14905324 wikiPageWikiLink Q332181.
- Q14905324 wikiPageWikiLink Q334848.
- Q14905324 wikiPageWikiLink Q4043525.
- Q14905324 wikiPageWikiLink Q409715.
- Q14905324 wikiPageWikiLink Q42395.
- Q14905324 wikiPageWikiLink Q428253.
- Q14905324 wikiPageWikiLink Q5156412.
- Q14905324 wikiPageWikiLink Q658145.
- Q14905324 wikiPageWikiLink Q6589727.
- Q14905324 wikiPageWikiLink Q7204727.
- Q14905324 type Biomolecule.
- Q14905324 type Protein.
- Q14905324 type Thing.
- Q14905324 type Q206229.
- Q14905324 type Q8054.
- Q14905324 comment "Integrin alpha M (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM is also known as CR3A, and cluster of differentiation molecule 11B (CD11B).".
- Q14905324 label "Integrin alpha M".