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- Q1384855 subject Q7329527.
- Q1384855 abstract "In genetics, expressivity quantifies variation in a non-binary phenotype across individuals carrying a particular genotype. It is equal to the proportion of individuals carriers of a genotype for a trait who show the trait to a specifiable extent (as in the "shades of blue" example below). This differs from penetrance, the term that measures how often a gene generates its associated phenotype to any extent that makes an individual carrier different from the wild type. Expressivity therefore characterizes non-binary qualitatively or quantitatively the extent of phenotypic variation within a particular genotype. With binary phenotypes (e.g., albino vs. wild type) expressivity and penetrance are the same. The term is analogous to the severity of a condition in clinical medicine. For example, the volume of blood ejected from the pumping heart with each contraction, relative to the total amount of blood contained in the heart's chamber can be quantified by echocardiography and is called the ejection fraction. If a specific genotype is associated with the development of congestive heart failure, the expressivity would be represented by the range of ejection fractions seen in patients that have that genotype. As a more qualitative example, in the hypothetical example of a "blue" gene, the gene might have an expressivity of 25% for individuals that express the "blue" gene and appear light blue, while for individuals who express the "blue" gene and appear dark blue, the expressivity might be 75%. Expressivity is measured only when there is 100% penetrance.".
- Q1384855 wikiPageExternalLink NBK22090.
- Q1384855 wikiPageWikiLink Q104053.
- Q1384855 wikiPageWikiLink Q106016.
- Q1384855 wikiPageWikiLink Q11190.
- Q1384855 wikiPageWikiLink Q1134884.
- Q1384855 wikiPageWikiLink Q128723.
- Q1384855 wikiPageWikiLink Q185055.
- Q1384855 wikiPageWikiLink Q216933.
- Q1384855 wikiPageWikiLink Q3733697.
- Q1384855 wikiPageWikiLink Q516389.
- Q1384855 wikiPageWikiLink Q584562.
- Q1384855 wikiPageWikiLink Q641303.
- Q1384855 wikiPageWikiLink Q7162.
- Q1384855 wikiPageWikiLink Q7187.
- Q1384855 wikiPageWikiLink Q7329527.
- Q1384855 wikiPageWikiLink Q7616509.
- Q1384855 wikiPageWikiLink Q80726.
- Q1384855 wikiPageWikiLink Q852654.
- Q1384855 wikiPageWikiLink Q853421.
- Q1384855 comment "In genetics, expressivity quantifies variation in a non-binary phenotype across individuals carrying a particular genotype. It is equal to the proportion of individuals carriers of a genotype for a trait who show the trait to a specifiable extent (as in the "shades of blue" example below). This differs from penetrance, the term that measures how often a gene generates its associated phenotype to any extent that makes an individual carrier different from the wild type.".
- Q1384855 label "Expressivity (genetics)".