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- Q12745555 subject Q7145822.
- Q12745555 abstract "An immunoreceptor tyrosine-based inhibition motif (ITIM), is a conserved sequence of amino acids (S/I/V/LxYxxI/V/L) that is found in the cytoplasmic tails of many inhibitory receptors of the immune system. After ITIM-possessing inhibitory receptors interact with their ligand, their ITIM motif becomes phosphorylated by enzymes of the Src kinase family, allowing them to recruit other enzymes such as the phosphotyrosine phosphatases SHP-1 and SHP-2, or the inositol-phosphatase called SHIP. These phosphatases decrease the activation of molecules involved in cell signaling. A list of human candidate ITIM-containing proteins has been generated by proteome-wide scans.".
- Q12745555 wikiPageWikiLink Q1059.
- Q12745555 wikiPageWikiLink Q10676833.
- Q12745555 wikiPageWikiLink Q142851.
- Q12745555 wikiPageWikiLink Q14905494.
- Q12745555 wikiPageWikiLink Q18030929.
- Q12745555 wikiPageWikiLink Q188017.
- Q12745555 wikiPageWikiLink Q242736.
- Q12745555 wikiPageWikiLink Q407997.
- Q12745555 wikiPageWikiLink Q421851.
- Q12745555 wikiPageWikiLink Q422476.
- Q12745555 wikiPageWikiLink Q7145822.
- Q12745555 wikiPageWikiLink Q79899.
- Q12745555 wikiPageWikiLink Q8047.
- Q12745555 wikiPageWikiLink Q8066.
- Q12745555 comment "An immunoreceptor tyrosine-based inhibition motif (ITIM), is a conserved sequence of amino acids (S/I/V/LxYxxI/V/L) that is found in the cytoplasmic tails of many inhibitory receptors of the immune system. After ITIM-possessing inhibitory receptors interact with their ligand, their ITIM motif becomes phosphorylated by enzymes of the Src kinase family, allowing them to recruit other enzymes such as the phosphotyrosine phosphatases SHP-1 and SHP-2, or the inositol-phosphatase called SHIP.".
- Q12745555 label "Immunoreceptor tyrosine-based inhibitory motif".