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- Q1255511 subject Q8253605.
- Q1255511 subject Q8862151.
- Q1255511 subject Q9008989.
- Q1255511 abstract "The Draize Test is an acute toxicity test devised in 1944 by Food and Drug Administration (FDA) toxicologists John H. Draize and Jacob M. Spines. Initially used for testing cosmetics, the procedure involves applying 0.5mL or 0.5g of a test substance to the eye or skin of a restrained, conscious animal, and then leaving it for set amount of time before rinsing it out and recording its effects. The animals are observed for up to 14 days for signs of erythema and edema in the skin test, and redness, swelling, discharge, ulceration, hemorrhaging, cloudiness, or blindness in the tested eye. The test subject is commonly an albino rabbit, though other species are used too, including dogs. The animals are euthanized after testing if the test renders irreversible damage to the eye or skin. Animals may be re-used for testing purposes if the product tested causes no permanent damage. Animals are typically reused after a "wash out" period during which all traces of the tested product are allowed to disperse from the test site.The tests are controversial. They are viewed as cruel as well as unscientific by critics because of the differences between rabbit and human eyes, and the subjective nature of the visual evaluations. The FDA supports the test, stating that "to date, no single test, or battery of tests, has been accepted by the scientific community as a replacement [for] ... the Draize test" Because of its controversial nature, the use of the Draize test in the U.S. and Europe has declined in recent years and is sometimes modified so that anaesthetics are administered and lower doses of the test substances used. Chemicals already shown to have adverse effects in vitro are not currently used in a Draize test, thereby reducing the number and severity of tests that are carried out.".
- Q1255511 thumbnail DraizeTest-PETA.jpg?width=300.
- Q1255511 wikiPageWikiLink Q104607.
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- Q1255511 wikiPageWikiLink Q8253605.
- Q1255511 wikiPageWikiLink Q82682.
- Q1255511 wikiPageWikiLink Q827658.
- Q1255511 wikiPageWikiLink Q8862151.
- Q1255511 wikiPageWikiLink Q8880.
- Q1255511 wikiPageWikiLink Q9008989.
- Q1255511 wikiPageWikiLink Q942326.
- Q1255511 wikiPageWikiLink Q948232.
- Q1255511 comment "The Draize Test is an acute toxicity test devised in 1944 by Food and Drug Administration (FDA) toxicologists John H. Draize and Jacob M. Spines. Initially used for testing cosmetics, the procedure involves applying 0.5mL or 0.5g of a test substance to the eye or skin of a restrained, conscious animal, and then leaving it for set amount of time before rinsing it out and recording its effects.".
- Q1255511 label "Draize test".
- Q1255511 depiction DraizeTest-PETA.jpg.