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- Q1232737 subject Q7171005.
- Q1232737 subject Q7334131.
- Q1232737 abstract "Perhexiline (Pexsig) is a prophylactic antianginal agent used primarily in Australia and New Zealand. Perhexiline is thought to act by inhibiting mitochondrial carnitine palmitoyltransferase-1. This shifts myocardial metabolism from fatty acid to glucose utilisation which results in increased ATP production for the same O2 consumption and consequently increases myocardial efficiency. Its clinical use has been limited by its narrow therapeutic index and high inter- and intra-individual pharmacokinetic variability. It was outlawed in many countries due to its adverse effects on poor metabolisers (PM). The product has been reintroduced for patients who have contraindications, or have not responded to other treatments for angina.".
- Q1232737 atcPrefix "C08".
- Q1232737 atcSuffix "EX02".
- Q1232737 casNumber "6621-47-2".
- Q1232737 chEBI "35553".
- Q1232737 drugbank "DB01074".
- Q1232737 fdaUniiCode "KU65374X44".
- Q1232737 iupacName "2-(2,2-dicyclohexylethyl)piperidine".
- Q1232737 pubchem "4746".
- Q1232737 thumbnail Perhexiline_structure.svg?width=300.
- Q1232737 wikiPageWikiLink Q1349821.
- Q1232737 wikiPageWikiLink Q14864427.
- Q1232737 wikiPageWikiLink Q2556789.
- Q1232737 wikiPageWikiLink Q323936.
- Q1232737 wikiPageWikiLink Q408.
- Q1232737 wikiPageWikiLink Q409205.
- Q1232737 wikiPageWikiLink Q465621.
- Q1232737 wikiPageWikiLink Q485680.
- Q1232737 wikiPageWikiLink Q5044069.
- Q1232737 wikiPageWikiLink Q510420.
- Q1232737 wikiPageWikiLink Q6531938.
- Q1232737 wikiPageWikiLink Q659446.
- Q1232737 wikiPageWikiLink Q664.
- Q1232737 wikiPageWikiLink Q7168.
- Q1232737 wikiPageWikiLink Q7171005.
- Q1232737 wikiPageWikiLink Q7187520.
- Q1232737 wikiPageWikiLink Q7334131.
- Q1232737 wikiPageWikiLink Q827450.
- Q1232737 wikiPageWikiLink Q945238.
- Q1232737 atcPrefix "8.0".
- Q1232737 atcSuffix "EX02".
- Q1232737 casNumber "6621".
- Q1232737 chebi "35553".
- Q1232737 drugbank "DB01074".
- Q1232737 iupacName "2".
- Q1232737 pubchem "4746".
- Q1232737 unii "KU65374X44".
- Q1232737 type ChemicalSubstance.
- Q1232737 type Drug.
- Q1232737 type ChemicalObject.
- Q1232737 type Thing.
- Q1232737 type Q8386.
- Q1232737 comment "Perhexiline (Pexsig) is a prophylactic antianginal agent used primarily in Australia and New Zealand. Perhexiline is thought to act by inhibiting mitochondrial carnitine palmitoyltransferase-1. This shifts myocardial metabolism from fatty acid to glucose utilisation which results in increased ATP production for the same O2 consumption and consequently increases myocardial efficiency.".
- Q1232737 label "Perhexiline".
- Q1232737 depiction Perhexiline_structure.svg.