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- Q1163287 subject Q7063594.
- Q1163287 subject Q9448303.
- Q1163287 abstract "In medicine, the clearance is a pharmacokinetic measurement of the volume of plasma that is completely cleared off of a substance per unit time. The usual units are ml/minThe total body clearance will be equal to the renal clearance + hepatic clearance + lung clearance. Although for many drugs the clearance is simply considered as the renal excretion ability, that is, the rate at which waste substances are cleared from the blood by the kidney. In these cases clearance is almost synonymous with renal clearance or renal plasma clearance. Each substance has a specific clearance that depends on its filtration characteristics. Clearance is a function of glomerular filtration, secretion from the peritubular capillaries to the nephron, and re-absorption from the nephron back to the peritubular capillaries. Clearance is variable in zero-order kinetics because a constant amount of the drug is eliminated per unit time, but it is constant in first-order kinetics, because the amount of drug eliminated per unit time changes with the concentration of drug in the blood. The concept of clearance was described by Thomas Addis, a graduate of the University of Edinburgh Medical School.It can refer to the amount of drug removed from the whole body per unit time, or in some cases the inter-compartmental clearances can be discussed referring to redistribution between body compartments such as plasma, muscle, fat.".
- Q1163287 thumbnail Physiology_of_Nephron.png?width=300.
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- Q1163287 wikiPageWikiLink Q9448303.
- Q1163287 comment "In medicine, the clearance is a pharmacokinetic measurement of the volume of plasma that is completely cleared off of a substance per unit time. The usual units are ml/minThe total body clearance will be equal to the renal clearance + hepatic clearance + lung clearance. Although for many drugs the clearance is simply considered as the renal excretion ability, that is, the rate at which waste substances are cleared from the blood by the kidney.".
- Q1163287 label "Clearance (medicine)".
- Q1163287 depiction Physiology_of_Nephron.png.