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- Q1047644 subject Q7145822.
- Q1047644 abstract "In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T cell receptor (TCR) molecules based upon the antigen binding specificity and therefore structure of their variable region. The word idiotype comes from two Greek roots, idio meaning 'private, distinctive, peculiar' and typos meaning 'mark.' Thus idiotype describes the distinctive sequence and region that makes any immunoglobing/TCR unique from others of the same type which is its variable region. The variable region of antigen receptors of T cells (TCRs) and B cells (immunoglobulins) contain complementarity determining regions (CDRs) with unique amino acid sequences. They define the surface and properties of the variable region, determining the antigen specificity and therefore the idiotope of the molecule. Immunoglobulins or TCRs with a shared idiotope are the same idiotype. Antibody idiotype is determined byGene rearrangementJunctional diversityP-nucleotides (palindromic nucleotides at sites of single-strand breaks)N-nucleotidesSomatic hypermutationsThe term idiotype is sometimes used to describe the collection of multiple idiotopes, and therefore overall antigen binding capacity, possessed by an antibody.The word idiotype became influential in immunology when Niels Jerne formulated his immune network theory. Jerne was awarded the Nobel Prize for Medicine or Physiology in 1984 largely for being the father of immune network theory. He defined idiotype as the set of epitopes on the V region of an antibody molecule, where epitope means an antigenic determinant. He also defined the "paratope" to be that part of an antibody variable region that binds to an antigen. The best developed version of immune network theory is called the symmetrical network theory, in which the distinction between idiotype and paratope plays no role.".
- Q1047644 thumbnail AntibodyChains.svg?width=300.
- Q1047644 wikiPageExternalLink IgTypes2000.htm.
- Q1047644 wikiPageExternalLink igs.htm.
- Q1047644 wikiPageWikiLink Q101929.
- Q1047644 wikiPageWikiLink Q103537.
- Q1047644 wikiPageWikiLink Q1432692.
- Q1047644 wikiPageWikiLink Q1472347.
- Q1047644 wikiPageWikiLink Q188930.
- Q1047644 wikiPageWikiLink Q193529.
- Q1047644 wikiPageWikiLink Q2396793.
- Q1047644 wikiPageWikiLink Q309876.
- Q1047644 wikiPageWikiLink Q3826179.
- Q1047644 wikiPageWikiLink Q412037.
- Q1047644 wikiPageWikiLink Q489135.
- Q1047644 wikiPageWikiLink Q5989022.
- Q1047644 wikiPageWikiLink Q6005434.
- Q1047644 wikiPageWikiLink Q6806451.
- Q1047644 wikiPageWikiLink Q7145822.
- Q1047644 wikiPageWikiLink Q79460.
- Q1047644 wikiPageWikiLink Q8066.
- Q1047644 comment "In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T cell receptor (TCR) molecules based upon the antigen binding specificity and therefore structure of their variable region. The word idiotype comes from two Greek roots, idio meaning 'private, distinctive, peculiar' and typos meaning 'mark.' Thus idiotype describes the distinctive sequence and region that makes any immunoglobing/TCR unique from others of the same type which is its variable region.".
- Q1047644 label "Idiotype".
- Q1047644 depiction AntibodyChains.svg.