Matches in DBpedia 2016-04 for { <http://doi.org/10.3109/00952990.2014.933840> ?p ?o }
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- 00952990.2014.933840 author "Ruffle JK".
- 00952990.2014.933840 date "Nov 2014".
- 00952990.2014.933840 date "November 2014".
- 00952990.2014.933840 doi "10.3109/00952990.2014.933840".
- 00952990.2014.933840 isCitedBy Addiction.
- 00952990.2014.933840 isCitedBy Alternative_splicing.
- 00952990.2014.933840 isCitedBy Amphetamine.
- 00952990.2014.933840 isCitedBy Disease_theory_of_alcoholism.
- 00952990.2014.933840 isCitedBy Epigenetics.
- 00952990.2014.933840 isCitedBy Ethanol.
- 00952990.2014.933840 isCitedBy FOSB.
- 00952990.2014.933840 isCitedBy Methamphetamine.
- 00952990.2014.933840 isCitedBy Methylphenidate.
- 00952990.2014.933840 isCitedBy NF-κB.
- 00952990.2014.933840 isCitedBy Neuropharmacology.
- 00952990.2014.933840 isCitedBy Nicotine.
- 00952990.2014.933840 isCitedBy Propofol.
- 00952990.2014.933840 issue "6".
- 00952990.2014.933840 journal "Am J Drug Alcohol Abuse".
- 00952990.2014.933840 journal "Am. J. Drug Alcohol Abuse".
- 00952990.2014.933840 journal "The American Journal of Drug and Alcohol Abuse".
- 00952990.2014.933840 pages "428–37".
- 00952990.2014.933840 pages "428–437".
- 00952990.2014.933840 pmid "25083822".
- 00952990.2014.933840 quote "Conclusions".
- 00952990.2014.933840 quote "Propofol is a general anaesthetic, however its abuse for recreational purpose has been documented . Using control drugs implicated in both ΔFosB induction and addiction , similar ΔFosB expression was apparent when propofol was given to rats. Moreover, this cascade was shown to act via the dopamine D1 receptor in the NAc, suggesting that propofol has abuse potential".
- 00952990.2014.933840 quote "The knowledge of ΔFosB induction in chronic drug exposure provides a novel method for the evaluation of substance addiction profiles . Xiong et al. used this premise to evaluate the potential addictive profile of propofol . Propofol is a general anaesthetic, however its abuse for recreational purpose has been documented . Using control drugs implicated in both ΔFosB induction and addiction , ...".
- 00952990.2014.933840 quote "The strong correlation between chronic drug exposure and ΔFosB provides novel opportunities for targeted therapies in addiction , and suggests methods to analyze their efficacy . Over the past two decades, research has progressed from identifying ΔFosB induction to investigating its subsequent action . It is likely that ΔFosB research will now progress into a new era – the use of ΔFosB as a biomarker. ...".
- 00952990.2014.933840 quote "The strong correlation between chronic drug exposure and ΔFosB provides novel opportunities for targeted therapies in addiction , and suggests methods to analyze their efficacy . Over the past two decades, research has progressed from identifying ΔFosB induction to investigating its subsequent action . It is likely that ΔFosB research will now progress into a new era – the use of ΔFosB as a biomarker. If ΔFosB detection is indicative of chronic drug exposure , then its monitoring for therapeutic efficacy in interventional studies is a suitable biomarker . Examples of therapeutic avenues are discussed herein. ...".
- 00952990.2014.933840 quote "Using control drugs implicated in both ΔFosB induction and addiction , similar ΔFosB expression was apparent when propofol was given ...".
- 00952990.2014.933840 quote "ΔFosB as a therapeutic biomarker".
- 00952990.2014.933840 quote "ΔFosB is an essential transcription factor implicated in the molecular and behavioral pathways of addiction following repeated drug exposure. The formation of ΔFosB in multiple brain regions, and the molecular pathway leading to the formation of AP-1 complexes is well understood. The establishment of a functional purpose for ΔFosB has allowed further determination as to some of the key aspects of its molecular cascades, involving effectors such as GluR2 , Cdk5 and NFkB . Moreover, many of these molecular changes identified are now directly linked to the structural, physiological and behavioral changes observed following chronic drug exposure . New frontiers of research investigating the molecular roles of ΔFosB have been opened by epigenetic studies, and recent advances have illustrated the role of ΔFosB acting on DNA and histones, truly as a ‘‘molecular switch’’ . As a consequence of our improved understanding of ΔFosB in addiction, it is possible to evaluate the addictive potential of current medications , as well as use it as a biomarker for assessing the efficacy of therapeutic interventions . Some of these proposed interventions have limitations or are in their infancy . However, it is hoped that some of these preliminary findings may lead to innovative treatments, which are much needed in addiction.".
- 00952990.2014.933840 quote "ΔFosB is an essential transcription factor implicated in the molecular and behavioral pathways of addiction following repeated drug exposure. The formation of ΔFosB in multiple brain regions, and the molecular pathway leading to the formation of AP-1 complexes is well understood. The establishment of a functional purpose for ΔFosB has allowed further determination as to some of the key aspects of its molecular cascades, involving effectors such as GluR2 , Cdk5 and NFkB . Moreover, many of these molecular changes identified are now directly linked to the structural, physiological and behavioral changes observed following chronic drug exposure . New frontiers of research investigating the molecular roles of ΔFosB have been opened by epigenetic studies, and recent advances have illustrated the role of ΔFosB acting on DNA and histones, truly as a ‘‘molecular switch’’ . As a consequence of our improved understanding of ΔFosB in addiction, it is possible to evaluate the addictive potential of current medications , as well as use it as a biomarker for assessing the efficacy of therapeutic interventions .".
- 00952990.2014.933840 quote "ΔFosB is an essential transcription factor implicated in the molecular and behavioral pathways of addiction following repeated drug exposure.".
- 00952990.2014.933840 title "Molecular neurobiology of addiction: what's all the FosB about?".
- 00952990.2014.933840 vauthors "Ruffle JK".
- 00952990.2014.933840 volume "40".